Health Mystery of higher risk of death for men

Mystery of higher risk of death for men

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A Covid-19-Patient is cared for in a hospital in Copenhagen. (Archive)

dpa

The Numbers are now unequivocal: men die more frequently of the Coronavirus disease. But why? Scientists to go to different assumptions.

Men of Coronavirus disease, a poorer prognosis than women. You can get often more difficult to Covid-19, and die more often. What seemed to be a phenomenon of China, with its high number of men Smoking, confirmed now in the world. Data of the research initiative Global Health 50/50 from more than 20 countries show that women are infected as often as men. In the case of mortality rates, the distribution is about one-third to two-thirds.

A guess: The often ungesündere life-style of men. Straight men of the older Generation, in the less on diet and lifestyle was respected, could be more suffering from pre-existing conditions. Conceivable is also, that men just go later to the doctor – and, therefore, diseases no longer procrastinate. Especially in the discussion of the so-called ACE2-Receptor, however, is that the Sars-CoV-2 Virus in the lungs can penetrate – he is according to a study, men in a higher concentration. The Team from the University Medical Center Groningen had studied the relationship between ACE2 and chronic heart failure and the gender difference noted. The reason for the higher concentration of ACE2 in men is not known, the researchers write in the “European Heart Journal”.



Cardiac cycle of key diseases?

The enzyme occurs in the lung, kidney, blood vessels, heart and gastrointestinal tract in appearance, is considered the portal of Entry for corona virus in the case of simple colds, as in the case of the corona virus-induced diseases Covid-19, Sars and Mers. Also in the case of Mers, men were more affected, says Bernhard Zwissler, Director of the clinic for anesthesiology at LMU University hospital in Munich. It’ll just investigated whether the administration of ACE-inhibitors as a blood pressure-lowering result is that cells produce more of the ACE2-Receptor, and thus are more prone to infection. It is conceivable, don’t be quite, be proven it yet.

Cardiovascular diseases are a risk factor for Covid-19 – and men are more affected by this than women. “From a Global perspective, it is so that men die more often of cardiovascular disease. But whether this is the key, we don’t know,” explains Spinner. He, too, sees in the different Regulation of the ACE2 receptor is a possible explanation, but warns if the interpretations of previous findings to caution.



The female hormone, protects Estrogen?

Some experts see as the factors for the different characteristics of the female hormone Estrogen, with its protective mechanism of action or the stronger immune system of women – and without that there is clear evidence. That the immune system of women to viral infections generally reacts faster and stronger than that of men, shows, according to virologists in other Virus diseases, such as for the influenza, Sars and Mers. Or in the case of simple colds – Quips about the “men-colds” seem to contain a core of truth. For this, women are more likely to suffer Auto-immune diseases in which the immune system überschiesst and its own cells attacks – a possible complication even in the case of Covid-19.

Countless studies are currently underway worldwide to Covid-19, gender-specific Differences. The doctors hope that the clarification of this question opens up new avenues for the treatment.


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