[메디컬투데이TV] Healthy obesity reduces the risk of developing Alzheimer’s disease

[메디컬투데이=최유진 기자] Domestic researchers found that if a person has a body mass index (BMI) of 25 kg/㎡ or more and does not have a metabolic disease that meets the diagnostic criteria for metabolic syndrome or is healthy and obese with one, Alzheimer’s is likely to develop. the infection is low.

On the 11th, a joint research team led by Professor Seong-Hoon Kang of the Department of Neurology at Korea University Guro Hospital (Professor Sung-Hoon Kang of the Department of Neurology at Korea University Guro Hospital and Professor Sang- Won Seo of the Department of Neurology at Samsung Hospital Seoul) analysis of the effects of stress and metabolic syndrome on the accumulation and progression of Alzheimer’s disease-causing substances has been published.

Although the relationship between weight and symptoms of Alzheimer’s disease was well known, there was no study that confirmed the effect on the symptoms of Alzheimer’s disease by considering metabolic syndrome, which is closely related to obesity.

Professor Kang’s research team examined the body mass of 1,736 Koreans aged 45 or older without dementia to determine the effect of weight status on brain imaging biomarkers for Alzheimer’s disease and vascular dementia according to the presence or absence of The presence of metabolic syndrome, and to analyze the effect of this relationship on cognitive decline.

Each group was further divided into a metabolic health group and a metabolic syndrome group according to the criteria of the metabolic syndrome, and the amyloid PET test results, brain MRI, and cognitive function were analyzed. The metabolic health group was defined as one or less metabolic syndrome diagnostic criteria (high blood pressure, high fasting blood sugar, high triglycerides, low HDL cholesterol) without waist circumference criteria.

As a result, the positive level of beta amyloid protein, which indicates the risk of amyloid accumulation, the causative agent of Alzheimer’s disease, was high in the overweight group (73.9%), but it was was lower in the obese group (37.0%), showing that obesity reduces amyloid accumulation.

When divided according to the presence or absence of metabolic syndrome, the positive levels of beta amyloid protein in the metabolic health obese group and the metabolic syndrome obese group were 29.6% and 42.5%, respectively, found the effect of obesity on the prevention of amyloid accumulation only when metabolically healthy showed a valid pattern.

The metabolically healthy obese group had thicker hippocampal volume, higher cognitive function scores, and the slowest decline in cognitive function during long-term follow-up.

Professor Seong-Hoon Kang said, “Through this study, it was determined that the presence or absence of metabolic syndrome influences the relationship between body weight and Alzheimer’s symptoms,” adding, “A ‘ considering that stress and metabolic syndrome can be corrected through diet, exercise, and medication, the results of this study “We expect that it will contribute to the prevention of dementia associated with Alzheimer’s disease by “maintain metabolic health and maintain an appropriate weight,” he said.

Meanwhile, this research paper, ‘Differential associations between body mass index (BMI) and Alzheimer’s symptoms according to metabolic health status’ was published in the latest issue of ‘Alzheimer’s Research & Therapy’, a renowned academic journal. associated with Alzheimer’s disease.

Medical Today Video Editing Team ([email protected])

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