“If the bowel is ruptured and leaky due to obesity…Onset, exacerbation of asthma, rheumatoid arthritis, dementia, etc.”
It has been revealed why asthma patients with severe symptoms need to lose weight. According to the results of a study by Nottingham Trent University in the United Kingdom, if the intestine is damaged by obesity and causes leaky gut syndrome, it causes asthma and worsens the symptoms.
When obesity causes a small hole in the inner wall of the intestine, “leaky gut” increases, resulting in leaky gut syndrome (leaky gut syndrome). Unlike when the intestine is normal, harmful substances such as various external toxins and germs (bacteria) invade it. In addition to asthma, leaky gut syndrome can cause various diseases such as rheumatoid arthritis, dementia, aging, ulcerative colitis and food allergies.
First author of the study, Nottingham Trent University researcher Kristina Parenti (PhD candidate), said: ‘There has been no study to date on the effect of leaky gut due to obesity on asthma. This is the first time that the mechanism of obesity-increased intestinal permeability-leaky gut syndrome-asthma exacerbation and onset has been identified. She pointed out that “toxins in the gut caused by obesity are the main culprits in worsening asthma symptoms.” Asthma, if not well controlled, can lead to complications such as fatal asthma attacks, lung infections and fatigue.
The research team studied the relationship between body weight and intestinal permeability in 98 patients (29 males and 69 females) with severe and poorly controlled asthma. The men’s mean age was about 53 years and their mean body mass index (BMI) was about 29 (kg/m2). The mean age of the women was approximately 46 years and the mean BMI was approximately 32 (kg/m2). The research team conducted a blood test to detect leaky gut markers (markers), lipopolysaccharide binding protein (LBP), calprotectin, and asthma-related inflammatory markers (granzyme-A, IL-5, IL-6, CCL -4). number has been measured.
Study results showed that patients with poorly controlled asthma had significantly higher levels of the leaky gut marker, and these levels increased as they gained weight. Furthermore, it was found that as the level (concentration) of LBP increased, so did the level of asthma-related inflammatory markers. An earlier study, the Norwegian University of Science and Technology, found that people with abdominal obesity were 1.44 times more likely to develop asthma than the general population. This is true when looking at just waist circumference, not whole-body obesity. People with abdominal obesity and general obesity had a 1.81 times higher risk of asthma.
Researcher Parenti said, “It improves intestinal wall function by improving food life, etc., and it is expected that the symptoms of asthmatic patients who are obese can be greatly alleviated.” In addition to the small number of patients with severe uncontrolled asthma, the research team plans to recruit a much larger number of patients with well-controlled asthma and conduct further research.
The results of this study (Investigation of the effect of obesity on intestinal damage, systemic inflammation, increased severity of asthma due to gut-derived bacteria, endotoxin) were presented at the recently held British Society for Endocrinology and presented from the American Society for the Advancement of Science portal ‘Eureka Alert’.
