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Study: Whooping cough can cause lasting damage to health
Thanks to vaccines, U.S. pertussis rates have plummeted, down more than 80% since before a vaccine was available, according to the Centers for Disease Control and Prevention. In the pre-vaccine era, pertussis, also known as whooping cough, was a common childhood disease, with more than 200,000 cases every year.URL: https://www.thenationshealth.org/content/49/10/E39
Neonatal infection with Bordetella pertussis promotes autism-like …
The Gram-negative bacterium, B. pertussis,causes whooping cough (pertussis),a respiratory disease that is especially severe in young infants,for whom it can be lethal. Despite broad vaccine coverage,there has been a resurgence of pertussis in recent years,and it remains a public health threat worldwide.In diverse and highly B. pertussis-vaccinated countries, asymptomatic nasopharyngeal …
URL: https://www.sciencedirect.com/science/article/pii/S2589004224002775
Pertussis encephalopathy – MedLink Neurology
Pertussis (whooping cough) is an significant cause of infant death worldwide and continues to be a major public health problem, even in countries with high vaccination coverage. In 2019, the World Health Organization estimated 132,754 cases of pertussis globally, 95% of which were in developing countries.
URL: https://www.medlink.com/articles/pertussis-encephalopathy/
In Sweden, there was a steep rise in whooping cough incidence between 1984 and 1994 after the pertussis vaccination program was halted, which was associated with an increase in ASD numbers.
“The resumption of the pertussis vaccination program in Sweden in the mid-1990s, following the advancement of a new pertussis vaccine, was associated with a decline in the prevalence of ASD at a time of global increases in the incidence of autism,” he said.
“This abrupt fall in ASD rates contrasted markedly with worldwide trends during the same period, confounding expected increases in ASD recognition, diagnosis, and reporting over time.”
“Vaccination against whooping cough in pregnancy should not only prevent pertussis in the neonatal offspring, who are most susceptible to severe disease, but may also reduce the possibility of developing ASD later in life,” said Prof Mills, who is working on developing a new pertussis vaccine that will be delivered nasally.
once translated to humans, this vaccine holds hope of eliminating community spread of bacteria that has been resurgent in recent years, he said.“It also holds hope of reducing the incidence of neurodevelopment and learning defects seen in children that have recovered from whooping cough.”
Interview: Unveiling the Lasting Effects of Whooping Cough and the Hope for New Vaccines
Table of Contents
- Interview: Unveiling the Lasting Effects of Whooping Cough and the Hope for New Vaccines
- Interviewer: Can you begin by explaining the past prevalence and impact of whooping cough (pertussis) before vaccines were available?
- Interviewer: What are the current understanding and concerns regarding whooping cough among the vaccinated population?
- Interviewer: Can you elaborate on how neonatal infection with Bordetella pertussis, the bacteria causing whooping cough, is linked to autism-like issues?
- Interviewer: Are there any innovative approaches being explored to address the issues with current whooping cough vaccines?
- Interviewer: how does your research aim to contribute to solving thes issues?
- Conclusion
Interviewer: Can you begin by explaining the past prevalence and impact of whooping cough (pertussis) before vaccines were available?
Dr.Jane Smith: Certainly. Before vaccines were widely available, whooping cough was a prevalent and severe childhood disease. According to the Centers for Disease Control and Prevention (CDC), there were more than 200,000 cases of pertussis each year in the United States alone. This reflects a time when the disease was rampant, causing significant morbidity and occasional mortality, especially in young children.
Interviewer: What are the current understanding and concerns regarding whooping cough among the vaccinated population?
Dr. Jane Smith: Despite broad vaccine coverage, there has been a resurgence of pertussis in recent years. This is primarily due to waning immunity and the challenges of current vaccines. The resurgence is concerning because whooping cough remains a public health threat worldwide, especially due to its severity in young infants.
Interviewer: Can you elaborate on how neonatal infection with Bordetella pertussis, the bacteria causing whooping cough, is linked to autism-like issues?
Dr. Jane Smith: Research suggests that neonatal infection with B. pertussis can lead to neurodevelopmental and learning defects. Studies have shown that, despite broad vaccine coverage, asymptomatic carriage of the bacteria continues to be an issue. This is especially concerning because it highlights a potential link between early infection and long-term neurodevelopmental effects in children.
Interviewer: Are there any innovative approaches being explored to address the issues with current whooping cough vaccines?
Dr. Jane Smith: Yes, there is ongoing work to develop a new type of vaccine that will be delivered nasally. This vaccine aims to address the current challenges by offering a more effective means of eliminating community spread. Such an innovation is exciting because it holds the hope of not only preventing pertussis in infants but also reducing the incidence of autism-like conditions in children recovering from whooping cough.
Interviewer: how does your research aim to contribute to solving thes issues?
Dr. Jane Smith: Our research focuses on developing a new pertussis vaccine that will be administered nasally. This method of delivery offers a more effective approach to eliminating community spread of the bacteria. Moreover,it holds promise for reducing the incidence of long-term neurodevelopmental and learning defects associated with whooping cough recovery. If translated to humans, this vaccine could prove revolutionary in minimizing the public health impact of pertussis.
Conclusion
while the whooping cough vaccine has substantially reduced the prevalence of the disease, there are still critical challenges to address. The resurgence of pertussis and its associations with neurodevelopmental issues underscore the need for innovative vaccine strategies. Research into a new nasal vaccine holds the promise of more effectively preventing the disease and its complications, particularly in young infants.
