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The British analysis workforce analyzed the medical information of greater than 110,000 individuals identified with nervousness after the age of fifty
A examine discovered that individuals newly identified with nervousness after the age of fifty have a threat of growing Parkinson’s illness later in life, which is greater than twice that of individuals with out nervousness.
In a paper printed within the British Journal of Normal Follow on the twenty fifth, Professor Juan Bajo-Avarez’s workforce at College School London (UCL) within the UK discovered that greater than 110,000 individuals have been identified with nervousness after the age of fifty and a management group of over 880,000 individuals who weren’t identified with nervousness.
Parkinson’s illness, which impacts greater than 10 million individuals worldwide, is taken into account to be the quickest rising neurodegenerative illness.
It’s recognized to be attributable to the buildup of a protein referred to as alpha-synuclein within the substantia nigra of the midbrain, which causes nerve cells to die or develop into broken, ensuing within the lack of the flexibility to launch dopamine. result in.
The analysis workforce defined the background to the examine by saying that though nervousness is understood to be a function of the early levels of Parkinson’s illness, the chance of Parkinson’s illness in sufferers who develop signs of hysteria newly after 50 years of age and the components that the chance has not been elevated.
On this examine, the analysis workforce used main care knowledge from 109,435 individuals newly identified with nervousness after age 50 and 878,256 individuals with out nervousness between 2008 and 2018 to find out the distinction in threat develop Parkinson’s illness because of nervousness after the age of fifty. .
From the time of the prognosis of hysteria to 1 12 months earlier than the prognosis of Parkinson’s illness, we discovered whether or not there have been any options of Parkinson’s illness, reminiscent of sleep issues, melancholy, tremors, and stability problems, and studied the dangers and threat components for growth. Parkinson’s illness in every group over time.
In consequence, the chance of growing Parkinson’s illness amongst individuals identified with nervousness after age 50 was 2.1 instances larger than amongst individuals with out nervousness, even after taking into consideration threat components reminiscent of age , gender, social deprivation, way of life components, severe psychological sickness. , head accidents, and melancholy
The incidence charges of Parkinson’s illness in individuals with and with out nervousness have been 1.02 and 0.49 per 1,000 person-years (a person-year is the worth of observing one particular person for one 12 months), respectively.
As well as, it has been discovered that sufferers with nervousness are at higher threat of growing Parkinson’s illness if melancholy, low blood stress, tremors, stiffness, stability problems, constipation, sleep problems, fatigue, and cognitive impairment.
If in case you have tremors, your threat of growing Parkinson’s will increase 21.3 instances, stiffness will increase your threat 5.1 instances, stability dysfunction 4.2 instances, low blood stress 4.0 instances, seizures 2.6 instances, problems sleep 2.2 instances, fatigue 1.8 instances, and melancholy 1.7 instances. hour.
Professor Baggio-Avarez mentioned, “This examine confirmed that nervousness and the traits that seem in sufferers with nervousness after the age of fifty are associated to the chance of growing Parkinson’s illness. ” I hope this occurs,” he mentioned.
◆ 출처 : British Journal of Normal Follow, Juan Bazo Avarez et al., ‘Threat of Parkinson’s illness in individuals > 50 years with new nervousness’, https://doi.org/10.3399/BJGP.2023.0423
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2024-06-24 23:30:05
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