This new discovery sparked the applause of a room packed with oncologists, researchers and industrialists, gathered in Paris for the annual congress of the European Society of Medical Oncology. Presented on September 11, 2022, the study showed that the combination of two immunotherapy treatments could produce a response rate “Without precedents“and so shrink the tumor by 95%according to Myriam Chalabi, lead author of the study and researcher at the Netherlands Cancer Institute in Amsterdam.
The current treatment offered to patients with Colon cancer it is a surgical procedure, which may or may not be followed by chemotherapy. In this study, patients were treated with a series of immunotherapy and then operated on a week or two later. Although it was conducted on a limited number of patients, 112 in total, the results are more striking: after the examination, 95% of tumors regressed by 90% and 99% of tumors regressed by more than 50%. Currently, conventional chemotherapy offers a less interesting therapeutic answer: only 5-7% of tumors regress by more than 50%.
However, this progress is only about 10-15%. non-metastatic colon cancerstumors with a genome abnormality leading to a breakdown of the DNA repair system (dMMR). A third of these anomalies are linked to a hereditary disease, (…)
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