He Alzheimer It is a type of dementia that, together with other neurodegenerative diseases of this type, affects around 900,000 people in Spain. These age-related pathologies are one of the main causes of mortality, disability and dependency. In Alzheimer’s disease there are two fundamental proteins: beta-amyloid and phosphorylated tau protein. Nowadays, it is known that an excess of the amyloid protein is what causes the appearance of the disease and that, after this protein, alterations in Tau appear.
There are multiple theories about the etiology of Alzheimer’s disease. (EA). One hypothesis is that infections may play a role in the development of AD and disease-related dementias, as they may increase neuroinflammation, thus causing or exacerbating neurodegeneration, and subsequently dementia.
Vaccines can reduce the risk of developing infections or limit their severity reducing an individual’s neuroinflammatory burden. A recent study from UTHealth Houston Scientific Research and Academic Center associated the administration of certain vaccines with a lower risk of Alzheimer’s disease in adults older than 65 years. It’s about the tetanus and diphtheria shot, with or without pertussis (Tdap/Td) herpes zoster (HZ), better known as shingles; and the pneumococcus.
The new findings come just over a year after the team led by Paul E. Schulz, a professor of neurology at McGovern School of Medicine in Houston and the study’s lead author, published another study detailing that people who had received at least one flu vaccine were 40 percent less likely than their unvaccinated peers develop the disease de Alzheimer.
In the new study, they found that people who received the vaccine Tdap for tetanus, diphtheria, and pertussis, as well as those given Td for the first of those two diseases had 30 percent less likely than their unvaccinated peers from developing Alzheimer’s disease (7.2 percent of vaccinated patients vs. 10.2 percent).
With the herpes zoster vaccine found a 25 percent reduction in the risk of developing Alzheimer’s disease, while with the pneumococcal vaccine there was an associated 27 percent reduction in the risk of developing the disease (7.92 percent of vaccinated patients vs. 10.9 percent of those unvaccinated patients)
“We wondered if the finding was specific to the flu vaccine. These data revealed that several additional vaccines for adults were also associated with a reduced risk of Alzheimer’sSchultz said. “We and others hypothesized that the immune system is responsible for causing brain cell dysfunction in Alzheimer’s disease. The findings suggest to us that vaccination has a more general effect on the immune system, which reduces the risk of developing Alzheimer’s disease.”
For this study, the research team analyzed a group of patients aged 65 or over who were free of dementia over a two-year period and carried out an eight-year follow-up. To do this, they compared those who were vaccinated with those who were not vaccinated and superimposed that comparison between those who developed Alzheimer’s disease and those who did not.
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2023-08-21 12:28:45
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