Administration of some of the infectious disease vaccines included in standard vaccination schedules is associated with a reduced risk of developing Alzheimer’s disease, according to a study published in the Journal of Alzheimer’ Disease. These data confirm research previously published in the same journalwho showed that influenza vaccination reduces the risk of Alzheimer’s disease by 40% compared to unvaccinated people.
The new results point to the importance of access to routine vaccination of adults, a method that is proving to be even more valuable for public health, with the potential to ensure control of both infectious diseases and Alzheimer’s disease.
The main conclusions:
The administration of the DTP (diphtheria-tetanus-pertussis) or DT (diphtheria-tetanus) vaccine decreased by 30% the risk of developing Alzheimer’s disease, compared to those who did not receive the vaccine, the condition being diagnosed in over 7% of vaccinated patients vs over 10% in the control group. Vaccination against herpes zoster/varicella reduced the risk of Alzheimer’s disease by 25% compared to the control group, with 8% of vaccinated people developing the condition, compared to nearly 117% among unvaccinated people. Regarding the pneumococcal vaccine, the risk was reduced by 27% by vaccination, with almost 8% of vaccinated people developing the disease, and in the control group about 11% of people being diagnosed.
The new retrospective cohort study enrolled more than 1.6 million patients without dementia diagnosed in the last 2-3 years before inclusion in the study and who were at least 65 years old. They were monitored for 8 years. Two similar groups of participants were compared, one comprising vaccinated and the other non-vaccinated individuals.
Photo source: Pixabay
The association of reduced risk of developing Alzheimer’s disease with vaccination against various pathogens suggests that the immune system may be involved in the brain cell dysfunctions present in this condition and that vaccination has implications for general immunity in addition to specific protection against an agent etiological. Vaccines can alter the way the immune system reacts to the build-up of toxic Alzheimer’s proteins.
At the same time, some of the vaccines protect against infectious diseases that associate neuroinflammation. Deciphering these processes could point to new ways to prevent the development of Alzheimer’s disease through vaccination, a method that could be easier than other approaches, such as the administration of anti-amyloid antibodies.
Read also:
2023-10-25 17:27:05
#STUDY #Routine #vaccination #adults #lowers #risk #Alzheimers #disease #Sentinel #report
