Delivery time2023-07-20 09:15
US research team “Corona 19 asymptomatic 1 out of 5 has HLA mutant gene”
(Seoul = Yonhap News) Reporter Lee Joo-young = It is known that about 20% of people who get the new coronavirus infection (Corona 19) do not have symptoms. A US research team found a genetic mutation that increases the possibility of asymptomatic corona 19 more than eight times.
Illustration of a mutant gene fighting the Corona 19 virus
People with the human leukocyte antigen (HLA) variant, ‘HLA-B*15:01’, have immune T cells ready to fight the Corona 19 virus, so the probability of asymptomatic after infection is more than eight times higher. [Vanette Tran 제공. 재판매 및 DB 금지]
A research team led by Professor Jill Hollenbach of the University of California, San Francisco (UCSF) published in the scientific journal Nature on the 20th that one in five asymptomatic patients after SARS-CoV-2 infection was infected with the human leukocyte antigen (HLA) gene. There is a mutation, and people with this mutation are more than eight times more likely to be asymptomatic.
According to previous studies, at least 20% of those infected with the COVID-19 virus do not show symptoms. Researchers have hoped that studying asymptomatic patients will reveal features of the immune system that rapidly clears the coronavirus after infection.
In this study, the research team tracked the infection and symptoms of Corona 19 using a smartphone app for 29,947 bone marrow registrants with blood samples to investigate whether HLA mutations could be the cause of asymptomatic Corona 19.
As a result, during the study period, 1,428 of the unvaccinated were tested positive for COVID-19 virus infection, and 136 of them reported no symptoms.
As a result of the research team analyzing the genes of asymptomatic infected people, it was found that 1 out of 5 people had an HLA mutation called ‘HLA-B*15:01’. In addition, those who inherited this mutation from both parents and had a pair were more than eight times more likely to remain asymptomatic than those who did not.
In addition, in a separate study, ‘HLA-B*15:01’ holders who had never been exposed to the Corona 19 virus before had immune T cells that responded to the protein of the Corona 19 virus that had some nucleotide sequences identical to proteins of other seasonal coronaviruses. turned out to be
This means that carriers of ‘HLA-B*15:01’ who have previously been exposed to the seasonal cold virus already have immunity to the COVID-19 virus and can quickly get rid of the COVID-19 virus before symptoms appear after infection. .
However, Professor Hollenbach said, “HLA mutations may be just one piece of the genetic puzzle behind asymptomatic COVID-19. It is hoped that this study of the immune response will lead to new treatments and vaccines in the future.”
Report via KakaoTalk okjebo
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