March 6, 2021
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“The University of Washington” found new evidence that antibodies in the “vaccine” could be less effective. When a COVID-19 mutation is found, and its effectiveness is not the same. Depending on the species
School of Medicine Research Washington University In the city of St. LouisUnited States Indicates that the new coronavirus pathogenesisCOVID-19 Mutant Can spread quickly and dodgeantibodyThat negate the power of the original virus that is the source of the pandemic
The researchers tested the antibody’s ability to neutralize the bacteria.Mutated virus 3 Species In the laboratory To assess whether these virus strains Is it possible to avoid the antibodies of the precursor strain of COVID-19?
The researchers tested the mutant virus and antibodies in the blood of people who recovered from theInfectiousNew strains of coronavirus (SARS-CoV-2) or Pfizer vaccination, including blood tests for hamsters and monkeys who received an experimental vaccine at the School of Medicine through the nose.
Mutated virus The B.1.1.7 (B.1.1.7) strain was first discovered in the UK. Was neutralized with the same level of antibodies used to neutralize the activity of the original virus. As for the other two mutant virus strains Need antibodies to neutralize 3.5-10 times more activity.
Subsequently, the researchers tested a monoclonal antibody or antibody that was reproduce in large quantities and able to neutralize the viral activity. The original breed was excellent. The researchers tested monoclonal antibodies against the virus. The three mutants And found different results ranging from ineffective to totally ineffective.
Because the mutant virus was modified multiple times, the researchers created a single modified viral patch. To analyze the effects of each mutation And found that the efficacy of antibodies against the virus All mutants are subject to a single change in amino acids in thorn proteins.
The change, known as E484K (E484K), was found in the virus. Mutant B.1.135 (B.1.135) strain, from South Africa. And B.1.1.248 (B.1.1.248) from Brazil, but not in B.1.1.7. From united kingdom
Michael S. Diamond, senior author of this study. Revealed that the virus that is mutated. Strain B. 1.135 It is widespread in South Africa. It might be the explanation of one vaccine tested in people with lower efficacy in South Africa than in the United States. Which is much less common to the mutated virus
“We do not yet know the exact impact of the three mutated viruses. But what is clear is that we need to continually screen for effective antibodies. As the mutant virus re-emerges and spreads. This could have implications for vaccines and antibody therapy strategies, ”said Diamond, a professor in the molecular microbiology and medicine and immunology department.
However, the results of the study were published in the journal Nature Medicine on March 4.
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