Allulose (D-Allulose) is a natural sugar that exists in nature, but it is classified as a “rare sugar” because it is very rare. Toshihiko Yada, a professor at the Institute of Medicine at Kansai Electric Power Hospital in Japan, has long-term research and found that allulose is more effective than semaglutide, Rybelsus, an oral weight loss drug that is currently well-known but only used for diabetic patients. In addition to reducing appetite and preventing obesity, the effect is also more long-lasting. The reason is that there are two “braking” mechanisms.
The Obesity Research Society of the Republic of China recently held its 13th annual meeting. This year, Chen Zhiyan, executive director of the society, invited Japanese scholar Toshihiko Yada to come to Taiwan to present the latest research. Since 2010, Toshihiko Yada has been studying the effects of allulose on DIO mice (obese mice induced by high-fat diet) for 13 years. Liu Canhong, chairman of the Obesity Research Society, said that allulose is a monosaccharide with completely zero calories and a structure that is almost mirror-image symmetrical to glucose. At present, humans can 100% synthesize this sugar.
Yada Toshihiko’s research found that allulose can also reduce blood sugar and inhibit food intake in obese mice compared with Rybelsus, a well-known oral weight loss drug. He gave allulose to obese mice while they were resting for 7 consecutive days. He found that the obese mice could reduce their food intake by 50%. When they measured their weight again, they reduced their weight by 10%. The speed was very fast, but the effect was insignificant. The occurrence decreases, and the effect of allulose is more long-lasting.
The reason is that when it acts on GLP1 enterocrine, there are two mechanisms at the same time, “like two brakes.” Chen Zhiyan, who is also the director of the Obesity Research Society, explained that allulose can act outside the brain through the peripheral vagus nerve. It can also directly act on the brain through the central effect, further regulating the neurons related to food intake to achieve the effect of reducing intake. When one path fails, the other will make up for it. “The brakes will not fail at the same time.” This is the main reason for the long-term effect. .
In addition, allulose has the taste and texture of sugar, but almost no calories. Compared with the International Agency for Research on Cancer, which recently listed the sweetener aspartame as a category 2B possible carcinogen, Toshihiko Yada said that current research It has been shown that allulose is not carcinogenic and has not been found to be addictive. It is hoped that one day further human clinical trials can be completed and it will become an ideal choice for improving diabetes and obesity in the future.
2023-10-21 20:10:00
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