Understanding the Link Between Gut Dysbiosis and Type 2 Diabetes: Insights from Dr. Oana Pop

“Gut dysbiosis, characterized by changes in the gut microbiome, has been associated with type 2 diabetes (T2D). In recent years, research has highlighted links between gut microbiome composition and glucose metabolism, inflammation and insulin resistance, all of which are factors involved in the pathogenesis of T2D.“, he says Dr. Oana Pop, specialist in diabetes, nutrition and metabolic diseases at Hyperclinic Medlife Oradeain material made for the stage RoDiabet.ro.

Devices involved:

1. Chronic inflammation : Intestinal dysbiosis can lead to increased intestinal permeability and activation of a chronic inflammatory response. This chronic inflammation can contribute to insulin resistance and damage to pancreatic beta cells.
2. Metabolic changes: The composition of the gut microbiome can affect glucose metabolism and insulin sensitivity through the production of metabolites and bioactive substances, which directly or indirectly affect glucose homeostasis.
3. Gut-brain interaction: Microorganisms can communicate with the central nervous system through the gut-brain axis and influence appetite regulation, energy metabolism and pancreatic function.

Therapeutic strategies aimed at correcting intestinal dysbiosis may offer a new approach in the management of T2DM. These may include the use of probiotics, prebiotics, selective antibiotic therapy, and dietary changes to promote a healthy gut microbiome.

Understanding the role of intestinal dysbiosis in the pathogenesis of DZT2 is an important challenge, but also an opportunity to develop new therapeutic strategies. Identifying and treating gut microbiome disorders may be a critical component in preventing and treating T2D.

Bibliography:

1. Cani, PD, Amar, J., Churches, MA, et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56(7), 1761-1772.
2. Karlsson, FH, Tremaroli, V., Nookaew, I., et al. (2013). Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature, 498(7452), 99-103.
3. Mardinoglu, A., Wu, H., Bjornson, E., et al. (2018). An integrative understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans. Cell Metabolism, 27(3), 559-571.
4. Musso, G., Gambino, R., Cassader, M. (2010). Interaction between gut microbiota and host metabolism susceptible to obesity and diabetes. Annu Rev Med, 62, 361-380.
5. Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. (2006). Gut microbiome associated with obesity with increased capacity for energy harvesting. Nature, 444(7122), 1027-1031.

Text made by Dr. Oana Pop, specialist in diabetes, nutrition and metabolic diseases at Hyperclinic Medlife Oradeafor the platform DIABETES. You can find more interesting materials about diabetes on Dr. Oana Pop’s social accounts: https://www.facebook.com/dr.oanapop and https://www.instagram.com/dr.oana_pop/.