TEMPO.CO, Jakarta – Liver Fibrosis is an abnormal wound repair response caused by various chronic liver injuries, characterized by diffuse excessive deposition of extracellular matrix (ECM) and anomalous hyperplasia of connective tissue, and can further develop into liver cirrhosis, liver failure or liver cancer.
Liver fibrosis occurs when healthy liver tissue becomes scarred and unable to function properly.
Quoted from Healthline, fibrosis is the first stage of liver scarring. Some fibrosis can be reversible.
Quoting from msdmanuals.com, if months or years of repeated or continuous damage occurs, fibrosis becomes widespread and permanent. Scar tissue can form bands throughout the liver, destroying the internal structure of the liver and impairing the liver’s ability to regenerate itself and function. Such severe scars are called cirrhosis.
Causes of Liver Fibrosis
Liver fibrosis occurs after a person experiences injury or inflammation of the liver. Liver cells stimulate wound healing. During this wound healing, excess proteins such as collagen and glycoproteins accumulate in the liver. Eventually, after much repair, the liver cells (known as hepatocytes) can no longer repair themselves. Excess protein forms scar tissue or fibrosis.
There are several types of liver disease that can lead to fibrosis, including:
– autoimmune hepatitis
– biliary obstruction
– iron advantage
– nonalcoholic fatty liver disease, which includes nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH)
– Hepatitis B and C viruses
– alcoholic liver disease
Symptoms of Liver Fibrosis
Quoting from Medical News Today, people with fibrosis usually don’t realize that they have it. This is because fibrosis rarely causes obvious symptoms. However, in the liver, fibrosis can:
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– Reduces overall function, including purifying blood, storing energy, and clearing infection
– Limits the ability of organs to regenerate
– Limiting blood flow in the organs
People usually start experiencing symptoms when the fibrosis progresses to cirrhosis. These early symptoms can vary, but some of the most common early indicators of cirrhosis include:
– bad appetite
– feeling weak
– unexplained fatigue
– unexplained weight loss
– nausea and vomiting
– mild discomfort or pain in the right upper abdomen
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2023-05-06 16:24:00
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