Books by Hossam Al-Shaqwiry
Wednesday, April 26, 2023 06:00 PM
is a disease Leukemia A disease that’s linked to genes, but it’s not usually hereditary — meaning it generally can’t be passed from parent to child. Most cases of leukemia are linked to specific risk factors you had during your life, some you can control and some you can’t. A genetic mutation in the DNA of blood cells can cause certain types of leukemia. The mutation can lead to abnormalities in your blood cells, and the number of malfunctioning blood cells in your system may eventually exceed the number of normal blood cells. Having too many mutated blood cells can prevent the bone marrow from continuing to produce healthy blood cells. healthcentral
When we say that this disease is hereditary and not hereditary, it means that the mutations in your DNA that make you more susceptible to infection were not passed on to you from a previous generation, but rather resulted from other influences during your life. These genetic mutations are called acquired.
And, for example, if, as a child, you were exposed to secondhand smoke, third party smoke, or other pollution day in and day out, your cells may start developing mutations early in your life. If you became a smoker in your teens or adulthood, or become obese, you may experience changes or mutations in your DNA later in life. Radiation, plastics and chemical pollutants in everyday life or at work can also lead to mutations in DNA years after exposure.
In contrast, inherited genetic mutations are passed from parents to their offspring during fertilization, either in the egg from the mother or the sperm from the father. Children born with an inherited gene mutation will be more likely to develop certain cancers associated with that mutation. Most experts suggest that the vast majority of leukemias are not hereditary.
What are the risk factors for leukemia?
There are individual and overlapping risk factors for the four main types of leukemia – acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), chronic lymphocytic leukemia ( CLL ) .
Risk factors for acute myelogenous leukemia (AML) include:AML) Wall ALL Certain genetic conditions, lifestyle habits, and blood disorders:
Neurofibromatosis – a disorder of the nervous system that causes tumors to grow on nerves
Fanconi anemia – a condition of the bone marrow that leads to decreased production of all types of blood cells
Klinefelter syndrome – a group of symptoms such as infertility and small testicle size that occurs in men who have two chromosomes X
Bloom syndrome – a syndrome associated with short stature, a higher risk of cancer, and genetic instability
Ataxia-telangiectasia – a rare neurodegenerative disease causing potentially severe disability
Down syndrome – a common condition associated with developmental disabilities and other health problems that occurs when a person has an extra copy of chromosome 21
smoking
Blood disorders Primary thrombocytopenia, myelodysplasia, and polycythemia vera
Exposure to certain chemicals and pollutants increases the risk of developing leukemia. The main chemical involved in AML is gasoline. Occupations or situations that increase exposure to benzene include working in:
Chemical plant
Petrol station
shoe manufacturing
Oil refinery business
rubber industry
Another chemical exposure linked to leukemia is Agent Orange, which was used extensively during the Vietnam War.
Individuals who have previously had radiotherapy or chemotherapy for another cancer are at increased risk of developing any of several types of leukemia at a later time.
2023-04-26 16:00:00
#leukemia #hereditary #disease
