The Universidad Mayor de San Andrés (UMSA) of La Paz will initiate a research to know the effectiveness of the vaccines against Covid-19 that were applied in Bolivia and so achieve determine the amount of antibodies they created in the people who were immunized.
This inquiry corresponds to phase four that is done to all vaccines when they go on the market. The previous three stages of clinical research are carried out before the vaccines are applied in humans, as explained to EL DUTY, RÓger Carvajal Saravia, general coordinator of the UMSA Emergency Operational Committee for the coronavirus.
“These phase four investigations are carried out in all countries of the world and in this case, in Bolivia, it will be carried out by the UMSA, through an agreement that arrived with the Ministry of Health. The tests will begin to be taken in the next few days in La Paz ”, he commented.
In order to carry out this study of the effectiveness of vaccines, the La Paz university met a series of requirements, including having the bioethical endorsement of the Departmental Health Service (Headquarters), train the medical brigades that will attend to the vaccinated and comply with the forms financing for the purchase of reagents, supplies and medical equipment, the latter has not yet been fulfilled, due to the importing pharmaceutical companies having had delays in their delivery.
Sample analysis
Carvajal said that after obtaining the supplies will install eight sampling points in different vaccination centers from the city of La Paz. He added that this research is expected to be carried out on at least 2,000 people, who will be volunteers. The only requirement is not to have received any anticovid dose yet, to be able to undergo the first test.
“Volunteers will have blood and saliva samples taken four times. The first will be before receiving his first dose, another when he is vaccinated for the second time, the third in 45 days and the last in 8 months, “he explained. In addition, demographic data of the participants will be collected by age, sex, social status or regions, all this to know in which group the immunization had a better response.
Volunteers will have their demographic data collected to determine the groups that responded best with immunization.
With the samples, the UMSA will analyze the effectiveness of each of the vaccines that have already been used in the country, which are; Sputnik V, AstraZeneca, Sinopharm, Pfizer and Janssen. There are three main immune responses that this study aims to discover.
The first thing is to verify the quantity IgG antibodies created by the doses in the serum (blood) of the patient.
The second is to identify the IgA antibodies in the secretion (saliva), which are antibodies located at the level of the airways, which protect from Covid infection.
“They inoculate us in the shoulder muscle and there antibodies are created in the cell, but these do not protect the respiratory or oral mucosa, so the virus can reach these pathways. This means that the person can continue to be infected with coronavirus, but not get sickThanks to the immunization, ”Carvajal explained.
For Carvajal this will be an important study, because it will be detected if the vaccines produce antibodies in the mucosa, which would anticipate the arrival of the virus and prevent contagion. “If in case these IgA antibodies are not verified, you will have to use the sterilizing vaccines that come in spray and that are sprayed in the nose and people’s mouths, which are already being tested in other countries ”, he said.
While the third point who seeks to know the UMSA is called cellular immune response, which in addition to creating the T cell (immune cells, whose main purpose is to identify and kill invading pathogens or infected cells), it would protect the human organism from all existing variants of Covid.
The University of San Simón de Cochabamba and the Gabriel René Moreno Autonomous University of Santa Cruz will also participate in this research, but they will begin the tests after UMSA, and will replicate the same protocols of La Paz.
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The Universidad Mayor de San Andrés (UMSA) of La Paz will initiate a research to know the effectiveness of the vaccines against Covid-19 that were applied in Bolivia and so achieve determine the amount of antibodies they created in the people who were immunized.
This inquiry corresponds to phase four that is done to all vaccines when they go on the market. The previous three stages of clinical research are carried out before the vaccines are applied in humans, as explained to EL DUTY, RÓger Carvajal Saravia, general coordinator of the UMSA Emergency Operational Committee for the coronavirus.
“These phase four investigations are carried out in all countries of the world and in this case, in Bolivia, it will be carried out by the UMSA, through an agreement that arrived with the Ministry of Health. The tests will begin to be taken in the next few days in La Paz ”, he commented.
In order to carry out this study of the effectiveness of vaccines, the La Paz university met a series of requirements, including having the bioethical endorsement of the Departmental Health Service (Headquarters), train the medical brigades that will attend to the vaccinated and comply with the forms financing for the purchase of reagents, supplies and medical equipment, the latter has not yet been fulfilled, due to the importing pharmaceutical companies having had delays in their delivery.
Sample analysis
Carvajal said that after obtaining the supplies will install eight sampling points in different vaccination centers from the city of La Paz. He added that this research is expected to be carried out on at least 2,000 people, who will be volunteers. The only requirement is not to have received any anticovid dose yet, to be able to undergo the first test.
“Volunteers will have blood and saliva samples taken four times. The first will be before receiving his first dose, another when he is vaccinated for the second time, the third in 45 days and the last in 8 months, “he explained. In addition, demographic data of the participants will be collected by age, sex, social status or regions, all this to know in which group the immunization had a better response.
Volunteers will have their demographic data collected to determine the groups that responded best with immunization.
With the samples, the UMSA will analyze the effectiveness of each of the vaccines that have already been used in the country, which are; Sputnik V, AstraZeneca, Sinopharm, Pfizer and Janssen. There are three main immune responses that this study aims to discover.
The first thing is to verify the quantity of IgG antibodies created by the doses in the serum (blood) of the patient.
The second is to identify the IgA antibodies in the secretion (saliva), which are antibodies located at the level of the airways, which protect from Covid infection.
“They inoculate us in the shoulder muscle and there antibodies are created in the cell, but these do not protect the respiratory or oral mucosa, so the virus can reach these pathways. This means that the person can continue to be infected with coronavirus, but not get sickThanks to the immunization, ”Carvajal explained.
For Carvajal this will be an important study, because it will be detected if the vaccines produce antibodies in the mucosa, which would anticipate the arrival of the virus and prevent contagion. “If in case these IgA antibodies are not verified, you will have to use the sterilizing vaccines that come in spray and that are sprayed in the nose and people’s mouths, which are already being tested in other countries ”, he said.
While the third point who seeks to know the UMSA is called cellular immune response, which in addition to creating the T cell (immune cells, whose main purpose is to identify and kill invading pathogens or infected cells), it would protect the human organism from all existing variants of Covid.
The University of San Simón de Cochabamba and the Gabriel René Moreno Autonomous University of Santa Cruz will also participate in this research, but they will begin the tests after UMSA, and will replicate the same protocols of La Paz.
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