One GMOT studyrecently published in the scientific press, reaffirms the protective role that this protein plays on the mitochondrial functionality of cancer cellsas reported by the UIB in a statement.
Breast cancer is a disease related to factors such as genetic predisposition, lifestyle and environment. It is estimated that around 20 percent of cases can be attributed to risk factors that can be modified, including obesity.
It is known that, in conditions of obesity, a alteration of substances secreted by adipose tissue cells that leads to an imbalance in the secretion of molecules related to the cell communication process, and, therefore, can affect processes such as cell proliferation, invasive growth, programmed cell death (apoptosis), the formation of new blood vessels (angiogenesis) and metastasis in tumor cells.
FUNCTIONING OF THE MITOCHONDRIA
This imbalance also affects the functioning of the mitochondria, a cell organelle involved in cell communication and is the main source of reactive oxygen species (ROS), which play an important role in tumor processes, as well as in cell proliferation and apoptosis.
The scientific community has not yet managed to clarify the biochemical mechanism that relates the iinflammation caused by obesity and cellular modifications that cause breast cancer.
Recently, the GMOT research team confirmed the essential role played by the estrogen receptor ERß to maintain mitochondrial functionality and avoid the invasiveness of breast cancer cell lines. Estrogen receptors, such as ERß, are proteins that recognize estrogens and make possible the interaction between these hormones and the mechanisms of cellular regulation to carry out their duties.
BIOGENESIS PROCESSES
The GMOT team has studied mitochondrial functionality and the invasive capacity of tumor cells, analyzing the processes of mitochondrial biogenesis and dynamics, as well asl State of oxidative stress and inflammation and motility in cell lines with different ratios of estrogen receptors ERα/ERß exposed to inflammatory treatment and hormonal conditions in obese postmenopausal women.
He has also studied the expression of the most important antioxidant genes and related to inflammation and mitochondrial functionality in breast cancer tumor biopsies and its relationship with alpha and beta estrogen receptors.
The results show how, with obesity, the presence of ERß allows maintain a more functional mitochondrial pool, with active mitochondrial biogenesis and dynamics, which means less production of reactive oxygen species and better mitochondrial metabolism. In addition, antioxidant enzymes remain active and prevent oxidative damage and, at least in part, invasiveness.
PROTECTIVE ROLE
Reveals the protective role played by ERß against pbiochemical processes that can lead to breast canceras well as the importance of the mitochondria in the development of the disease.
It highlights the need to carry out more studies to clarify the mechanism of ERß in breast cancer and establish it as a possible clinical biomarker that makes it possible to advance towards more personalized treatments in the fight against this type of cancer.
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