Genube CI / Genube
GENUV announced on the 5th that it has discovered that brain nerve regeneration increases by more than 2.7 times and memory improves by about 2-fold through the expression of specific genes involved in brain nerve cell differentiation.
Through preclinical testing of ‘SNR1611 (ingredient name: trametinib)’, a drug candidate currently under development for the treatment of Alzheimer’s disease, GENUV inhibits MEK1/2 protein signaling, one of the overactivated cytoplasmic enzymes ‘mitogen-activated protein kinase (MAPK)’. It was confirmed that the expression of genes related to neuronal differentiation specifically increased.
In addition, it was demonstrated that differentiation of new nerve cells from neural stem cells is induced through this gene expression.
Trametinib (SNR1611) increases neuronal neogenesis in the cerebral cortex (A) and hippocampus (B) of Alzheimer’s disease model mice / GENUB
When ‘SNR1611’ was administered to an Alzheimer’s disease-induced animal model, nerve regeneration in the dentate gyrus, the inner region of the hippocampus responsible for memory, and the subventricular zone, the lower region of the paraventricular system, increased compared to the non-administered group. They increased by about 176.3% and 295.2%, respectively.
In addition, nerve regeneration was induced in the brain cortex, which is damaged by Alzheimer’s disease, after administration of ‘SNR1611’, and memory also improved by 102.1% in the ‘SNR1611’ administration group compared to the non-administration group.
The preclinical results were published in the latest issue of ‘Experimental & Molecular Medicine’ (impact factor 12.8), a sister journal of Nature.
CEO Han Seong-ho said, “Through this study, we confirmed that ‘SNR1611’ can activate neural stem cells that already exist in the brain to generate new nerve cells and protect existing nerves,” adding, “Maintaining neural homeostasis.” “This new concept treatment strategy could be applied to clinical trials for Alzheimer’s disease in the future,” he said.
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2023-10-05 05:36:33
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