Jakarta, Beritasatu.com – Head of the Institute for Molecular Biology (LBM) Eijkman, Amin Soebandrio said, the dendritic vaccine development process is as the name implies, then it uses flood dendritic of the subject of the person to be vaccinated. As is known, dendritic cells are the main ingredient in development Nusantara vaccines.
In this case, technically the formation of dendritic cells starts from taking white blood cells from the veins of the person to be vaccinated and then separated, known as monocytes.
Amin explained, these separated monocyte cells are then transferred from spike to draw blood and put in a tube for monocyte cells, so that they are cultured into dendritic cells. The monocyte cells are part of the cells of the human body.
“After the dendritic cells, will be introduced to the antigen that has been prepared. It depends on what kind of vaccine we want to make. For example, to make a cancer vaccine, cancer antigen or something else is used according to the vaccine to be made, “said Amin at the Trijaya Polemic virtual dialogue event about” Who Likes Nusantara Vaccines “, on Saturday (17/4/2021).
Amin explained, the dendritic cells used for SARS CoV-2, then use a protein that has been prepared in such a way to introduce dendritic cells.
“This dendritic cell works, it swallows first because the cell recognizes it as a foreign object. If the protein is our body’s own protein, it will not be swallowed up by dendritic cells, “he said.
Amin explained, this foreign protein is known from a molecular known as antigen presenting cell (APC) or antigen-presenting cells. Then, the APC will ingest the antigen in the form of a given protein because the dendritic cells recognize it as a foreign object. The antigen will be digested in the APC into small pieces.
“Our bodies are extraordinarily sophisticated. They will recognize cells including cells in our own bodies with foreign protein cells, so that these proteins will be swallowed up by cell dendritics and digested. “This means that it is cut into pieces so that they appear again or are presented as antigens together with several other molecules to help with ingestion,” he explained.
Amin said that the antigen that has appeared on the surface will be injected back into the person’s body. Then stimulate the arrival of immune cells, namely T and B cells.
In this case, for the antigen that comes from SARS CoV-2, the T and B cells and built are aimed at being part of the SARS CoV-2 virus. The way it works, these cells must be given the same person because each cell has an identity like a KTP. In this case, the same cells must be inserted into the same body.
“We say this dendritic vaccine is an individual vaccine because blood from a certain person is then processed and must be entered for the same person,” he said.
Source: BeritaSatu.com
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