The three senior players were not brought by coach Luis Enrique to this year’s tournament in Qatar.
Spain are facing their 12th consecutive World Cup with the hope of returning to the pinnacle of glory after doing so in 2010.
They are not in an easy group, having to contend with the 2014 World Cup champions Germany, as well as Asian giants, Japan and dark horses Costa Rica.
Luis Enrique, who has a good track record with the Spanish national team, has a lot of talent to rely on and has already decided which players to call up for his squad.
The Barcelona trio of Pedri, Gavi and Ansu Fati are among the team’s future stars, while seasoned veterans such as Sergio Busquets, Cesar Azpilicueta and Alvaro Morata know what it takes to compete at the highest level.