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The simultaneous treatment of rheumatism and cognitive impairment is open / Desk ::::: Art

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Of course, it is an organ abnormality in the most severe cases

Rheumatoid arthritis with cognitive impairment

Meanwhile, the focus has only been on relieving inflammation.

There was.

Cognitive impairment and cognitive impairment

Simultaneous treatment paved the way.

Treatment includes dementia medications in clinical trials

It is getting more and more attention.

Journalist Cho Hyung-chan reports.

◀ Report ▶

Rheumatoid arthritis is genetic and environmental

In addition to immunity, we need to protect our body

Inflammation and inflammation when immune cells rush to the joints

It is an autoimmune disease that causes damage.

Scleritis, interstitial pneumonia and purpura

Accompanying, the inflammatory response also affects the brain,

It can cause depression and cognitive impairment

The cause was a labyrinth.

A Korean research team found that rheumatoid arthritis patients

They coexist in the joints and star cells of the brain

The Maobi enzyme is the common pathogenesis of both diseases

He was the first to discover that he was a human being.

Maobi inhibits signal transduction in nerve cells.

Activates a neurotransmitter called GABA.

If “KDS2010” is administered, which inhibits Maobi, joint inflammation and cognitive function are restored.

want.

Woojin Won / Researcher, Center for Cognitive Sociality, Institute for Basic Science

“Previous studies have shown that immune cells and

If the goal was to reduce inflammation

The mechanism of the goal has now been revealed. “

This was also confirmed by animal experiments.

KDS2010 is currently used for Alzheimer’s and other dementias.

It is receiving more attention as it is in clinical trials as a treatment

there is.

Simultaneous treatment of arthritis, cognitive impairment and dementia

Duration of development of a possible next generation rheumatoid treatment

It’s open.

Chang-Jun Lee / Director, Center for Cognitive and Social Studies, Institute of Basic Science

“In dementia, we found that the Maobi of reactive star cells

Because enzymes have been shown to be the cause

When this is suppressed by the same mechanism

Rheumatoid animals as animal models of dementia

Cognitive impairment was improved by inhibition in the model

It’s done.”

The results of this study were published in the world’s top 10 molecular medicine journal.

Official Journal of the Korean Society of Biochemical and Molecular Biology

It was published in ‘Experimental Molecular Medicine’.

This is MBC News Cho Hyung-chan.//

(Video coverage: Shin Shin-ho)

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