Delivery time2023-06-29 06:13
Results of 17-year analysis of 3.06 million people with cardiovascular disease… “If you take it for preventive purposes, it doubles the risk of death.”
aspirin
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(Seoul = Yonhap News) Reporter Kim Gil-won = An analysis has been conducted that the risk of death after a cerebral hemorrhage increases significantly if the elderly who do not have cardiovascular disease take low-dose aspirin for a long time.
National Health Insurance Ilsan Hospital Department of Rehabilitation Medicine Professor Kim Hyung-seop research team announced on the 29th that they analyzed the primary preventive effect of aspirin on 3.06 million people aged 55 or older who first suffered from cardiovascular disease using big data from the National Health Insurance Service.
Aspirin, an anti-inflammatory analgesic, is a drug widely used for the purpose of preventing recurrence in patients who have suffered cardiovascular diseases such as myocardial infarction or stroke.
However, there is a lot of controversy over the efficacy of using aspirin for the purpose of preventing cardiovascular disease in people who do not have cardiovascular health problems.
The research team divided the group who took aspirin before cardiovascular disease (8,770 people) and the group who did not take it (17,540 people) to determine the mortality rate after stroke for 17 years (2004-2021). compared
As a result, in the case of hemorrhagic stroke, the risk of severe brain lesion disability was higher in the group who took aspirin in advance.
In addition, short-term mortality and long-term mortality within 90 days were 33% and 6% higher in the group who took aspirin in advance than in the control group, respectively.
In the case of short-term mortality, the most important risk factor was age. Among the aspirin-taking groups, the short-term risk of death in those in their 60s, 70s, and 80s was 2.21 times, 3.63 times, and 6.69 times higher than those in their 60s, respectively.
Hazard ratios of mortality at 90 days after hemorrhagic stroke by age and sex in the aspirin-taking group. [논문 발췌]
The results of this study are in the same context as recent analyzes conducted abroad.
According to a paper published in the international journal ‘NEJM’ (New England Journal of Medicine) in 2018, as a result of the ‘ASPREE’ (Aspirin in Reducing Events in the Elderly) study targeting elderly people aged 65 years or older, people without cardiovascular disease prevented Taking aspirin for this purpose was observed to increase mortality by 14%. This trend was more pronounced in the elderly over 74 years of age.
The American Heart Association (ACC) and the American Heart Association (AHA) recommend that only patients who have suffered a myocardial infarction, stroke or who have undergone thoracic surgery take low-dose aspirin for the purpose of preventing secondary diseases.
The United States Special Committee on Disease Prevention and Prevention (USPSTF) also presented new aspirin dosage guidelines through a paper published in the Journal of American Medical Association (JAMA) last year. The key is not to start taking low-dose (81-100 mg) aspirin for the primary prevention of myocardial infarction or stroke for the elderly over 60 years of age.
In this thesis, the special committee revealed that daily intake of aspirin increased the risk of gastrointestinal bleeding such as gastric ulcer by about 60%, and the risk of brain hemorrhage by 20 to 30% depending on the type of bleeding.
Professor Kim Hyung-seop said, “Recent domestic and international studies have found that it is not advisable to use aspirin for primary disease prevention in the elderly who have not had cardiovascular disease.” It is more beneficial to take aspirin in terms of doing it.”
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