Jakarta, CNBC Indonesia – There is a lot of discussion about the news of a blood clotting case that is said to be related to the vaccine. The vaccines in question are the AstraZeneca and Johnson & Johnson (J&J) COVID-19 vaccines.
Until now, scientists around the world continue to find out and understand why the two vaccines can cause blood clots. Although rare, this condition can be potentially deadly.
“Understanding the causes is very important for the next generation of vaccines, because the Corona virus will stay with us and vaccinations will most likely become seasonal,” said Eric Van Gorp, a professor at Erasmus University, the Netherlands. 2021).
In Germany, a researcher claims to have discovered what triggers the blood clot. This was stated by a researcher, Prof. Andreas Geinacher and his team at Greifswald University.
They believe a vaccine with an adenovirus platform aimed at fighting the virus can cause an autoimmune response that causes blood clots to clot. According to Prof Geinacher, the reaction could be attributed to stray proteins and a preservative he found in the AstraZeneca vaccine.
Prof Geinacher and his team have also recently started examining the J&J vaccine, having identified more than 1,000 proteins in the AstraZeneca vaccine that come from human cells. Apart from that, he also discovered a preservative known as ethylenediaminetetraacetic acid or EDTA.
Their hypothesis is that EDTA, which is common for drugs and other products, helps these proteins enter the bloodstream, where they bind to a blood component called platelet factor or PF4 to form a complex that activates antibody production.
The inflammation caused by the vaccine combined with the PF4 complex can trick the immune system into believing the body is infected with bacteria. This triggers ancient defense mechanisms which then go out of control and cause clotting and bleeding.
On the other hand, Prof. John Kelton from McMaster University in Canada also tested patients with symptoms of post-vaccination blood clots. They replicated some of Prof. Geinacher’s research and confirmed his findings. However, the cause is still unclear.
“The (Prof. Geinacher) hypothesis could be true, but it could also be wrong,” said Prof. Kelton.
(dru)
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