There was a small portion of the transplanted liver with a cumulative lifespan of over 100 years, the researchers said.
The researchers say they have studied these livers for characteristics to determine why these organs are so flexible, paving the way for consideration of the potential expansion of use of older donor livers.
“The liver is a very flexible organ,” said study lead author Yash Kadakia of the University of Texas Southwestern Medical Center in Dallas.
“We use an older donor, we have better surgical techniques, we have advances in immunosuppression and we have a better match between donor and recipient factors. All of these things allow us to achieve better results, ”Kadakia added.
For the study, the results of which will be presented at the 2022 American College of Surgeons (ACS) Clinical Conference Scientific Forum, the team used United Network for Organ Sharing (UNOS) STAR files to determine which livers had a lifespan. cumulative life (initial total life at transplant plus survival). ) after transplantation) for at least 100 years.
Of the 253,406 livers transplanted between 1990 and 2022, 25 met the criteria for a 100-year liver, which has a cumulative lifespan of over 100 years.
“We looked at pre-transplant survival – basically, the donor’s age – and how long the liver takes to survive in the recipient,” Kadakia said.
“We stratified this extraordinary liver with a survival rate of over 100 years and identified donor factors, recipient factors and transplant factors that helped create this unique combination in which the liver can live up to 100 years,” added Kadakia.
For 100 liver centurions, the mean donor age was significantly higher, 84.7 years, compared with 38.5 years for unofficial liver transplants.
For the liver to reach 100, the researchers hoped to find an older donor and a healthier donor. Notably, cohort 100 donors had lower rates of diabetes and infections than donors.
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(This report was published as part of the auto-generated merge harness summary. Other than the title, ABP Live made no changes to the copy.)
