This vitamin has a very important role on the mental and emotional state, doctors say.
Vitamin D deficiency is the most underdiagnosed and undertreated nutritional deficiency in the world.
Recent studies have shown a high prevalence of vitamin D deficiency in patients with psychiatric disorders, including depression. They subsequently affirmed the importance of screening for vitamin D deficiency in patients with depression.
The link between vitamin D deficiency and depression stems from vitamin D’s role in brain development, synaptic plasticity, neuronal development, and protective factors against oxidative stress, according to newsmed.ro.
“Serum vitamin D levels are inversely correlated with clinical depression, but the evidence is not strong enough to recommend universal supplementation in depression. Enriching depression treatment trials with subjects with concomitant vitamin D deficiency appears to be a potential step forward in identifying the subgroups that could benefit the most from this approach,” he says conclusions of the US National Institutes of Healthwho studied over 60 medical articles on the link between Vitamin D deficiency and depression.
“The role of vitamin D in depression has received increased research attention. Currently, there are at least three lines of evidence supporting this association: first, a region-specific increased expression of vitamin D receptors (VDR) in areas of the brain (such as the prefrontal and cingulate cortices), which are known to play a key role in mood regulation.Secondly, the modulatory role of vitamin D in the association between depression and inflammation (through a possible immune-modulatory mechanism). Finally, the emerging knowledge about the neuroprotective properties of vitamin D (by virtue of its anti-inflammatory effects).” the American Institute of Health also shows.
The relationship between vitamin D and mental status
A synthesis of studies published online in 2019 brought to the fore the link between vitamin D deficiency and mood swings, highlighting the following issues:
Vitamin D receptors are present in the tissues and cells that enter the structure of the nervous system, the vitamin playing the role of a neurosteroid hormone in areas related to neurotransmission and neuroprotection. Its action as a neurosteroid hormone is fundamental in the activation of hormones and enzymes involved in the metabolism of neurotransmitters In the production of the active form of vitamin D, 1,25(OH)2 vitamin D3, a vitamin D receptor and 1 α-hydroxylase, which are found in an adult’s brain- They have been identified in glial and neuronal cells, in certain layers and subregions of the brain, such as in the cerebellum and in the cortex Vitamin D deficiency as a result of insufficient exposure to sunlight or due to an unbalanced diet leads to certain mutations at the level of its receptors, also causing major or minor mood swings A normal vitamin D receptor is responsible for regulating the glucocorticoid signal (glucocorticoids are hormones secreted by the adrenal glands), which however becomes dysfunctional in the case of vitamin deficiency A glucocorticoid signal dysfunctional causes disorders such as: depression, fatigue, loss of energy, inability to concentrate, up to major depression accompanied by thoughts of suicide
Signs of vitamin D deficiency
To realize that it is possible to face something like this, you should be able to notice, along with frequent depressive states or irritability and manifestations such as:
You get infections more easily (vitamin D deficiency has a negative impact on the immune system) You often have back pain, bone or muscle pain You feel muscle weakness You feel tired all the time In the case of a severe vitamin D deficiency there is a loss of bone density and can install osteoporosis
2023-08-08 03:00:02
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