Severe inflammation during infancy increases the risk of developing neurological disorders such as autism spectrum disorder and schizophrenia, according to a recent study.
A research team from the University of Maryland School of Medicine conducted a study to investigate the effects of inflammation on the brain. They examined postmortem brain tissues from 17 children who died between the ages of 1 and 5. Eight of the children had died from inflammatory-related diseases, while the other nine died from accidents. The two groups were similar in terms of age, gender, race, and time of death, and none of them had been diagnosed with neurodevelopmental disorders before their deaths. It was confirmed that the children who died from inflammatory diseases had been affected by bacterial or viral infections, as well as asthma.
The analysis conducted by the research team revealed that children who experienced severe inflammation had an early disruption in the maturation of Golgi
How does severe inflammation during infancy contribute to an increased risk of developing neurological disorders such as autism spectrum disorder and schizophrenia?
Severe inflammation during infancy has been found to increase the risk of developing neurological disorders, such as autism spectrum disorder and schizophrenia, according to a recent study conducted by researchers from the University of Maryland School of Medicine.
The study involved examining postmortem brain tissues from 17 children who passed away between the ages of 1 and 5. Eight of these children had died from diseases related to inflammation, while the other nine had died from accidents. The two groups were comparable in terms of age, gender, race, and time of death. None of the children had been diagnosed with neurodevelopmental disorders prior to their deaths.
Analysis of the brain tissues confirmed that the children who had died from inflammatory diseases had been affected by bacterial or viral infections, as well as asthma.
The research team’s analysis revealed that children who had experienced severe inflammation during infancy showed an early disruption in the maturation process of Golgi. This is a cellular structure involved in the processing and transport of proteins within cells. Any disruption in Golgi maturation can have a significant impact on normal brain development and functioning, potentially leading to the development of neurological disorders later in life.
These findings highlight the importance of early identification and treatment of inflammation in infants, as it may play a crucial role in preventing the development of neurological disorders. Further research is needed to better understand the mechanisms through which inflammation affects brain development and to develop strategies for mitigating its negative effects.
Wow, this is such an important topic to explore and understand. #NeurodevelopmentalDisorders #InflammationResearch
David:
I didn’t realize there was a potential link between inflammation in infancy and neurodevelopmental disorders. This definitely needs more attention and research. #HealthScience #ChildDevelopment