Research shows that cardiac mesenchymal stromal cells release a large number of extracellular vesicles (EVs) to repair the heart. However, the biomolecules wrapped in them also have the property of promoting the proliferation and migration of tumor cells; the picture is a contextual photo. (Picture taken from freepik)
Ye Libin/Editor
[Health Channel/Comprehensive Report]Are you more likely to develop cancer after suffering from myocardial infarction? Huang Xuan, a thoracic and critical care specialist, said that although the two share common risk factors, such as obesity, smoking, and type 2 diabetes, which are factors that promote cancer lesions, a study published in the journal Circulation showed that Cardiac mesenchymal stromal cells release a large number of extracellular vesicles (EVs) to repair the heart. However, the biomolecules wrapped in them also have the property of promoting tumor cell proliferation and migration.
What are extracellular vesicles? Huang Xuan’s Facebook fan page “Dr. Ooi Hean“The article points out that EVs play an important role in maintaining normal cardiac structure and function under physiological conditions, and change their composition under pathological conditions to promote the development of cardiovascular diseases; EVs serve as a unique intercellular communication form, can also promote cancer cell growth and survival, help shape the tumor microenvironment, and increase invasiveness and metastatic activity.
Huang Xuan said, but tracing back to the source, when EV reaches malignant tumors or precancerous tissues through blood circulation, it will promote the proliferation and migration of tumor cells. That is to say, EVs released from the heart after myocardial infarction mainly come from cardiac tissue damage and are activated during repair. They are small extracellular vesicles of cardiac mesenchymal stromal cells, referred to as cMSC-sEVs. cMSC-sEV can transform macrophages into a pro-tumor phenotype, promote macrophages to participate in inflammatory responses in many parts of the body, override the regulation of the immune system, the formation of new blood vessels, and new extracellular matrix remodeling, creating More cMSC-sEVs.
Huang Xuan went on to say that these conditions create favorable conditions for tumor growth and spread. According to the researchers, cMSC-sEV can accelerate the proliferation and migration of lung cancer and colorectal cancer cells, but has less impact on melanoma and breast cancer cell lines.
Huang Xuan believes that there is such a relationship between myocardial infarction and cancer. In addition to providing transportation to repair the damaged heart, it also accelerates the development of tumors. This study not only learns about the relationship between cardiovascular disease and cancer, but also provides a new treatment idea. Perhaps in the future, scientists can reduce the risk of cancer in patients with cardiovascular disease by regulating the production and function of cMSC-sEV. .
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2024-04-02 03:44:00
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