U.S. molecular biology researchers develop experimental messenger vaccine with HIV messenger RNA and test it successfully in experiments on rhesus mice and monkeys .
“We have been developing HIV vaccines for almost 40 years, but so far this task has not been solved. create a vaccine against the immunodeficiency virus, “he said. NIAID Director Anthony Fauci, quoted by the institute’s press service.
Like RNA vaccines for COVID-19, this drug consists of special fatty nanoparticles that contain an RNA fragment that encodes some of the immunodeficiency virus’s proteins. These nanostructures can penetrate human cells and cause them to produce a large number of fragments of the HIV protein coat, which theoretically leads to the formation of an immune response to the virus.
In this case, as Fauci noted, scientists have simultaneously chosen two “targets” for the immune system – the env protein, which forms the basis of the HIV envelope, and the gag protein, which plays the role of the internal skeleton of viral particles. Their combination, as biologists have suggested, should reduce the likelihood that changes in the structure of the HIV envelope will make it immune to the action of the vaccine.
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