“The higher the dose of statins, the more effective it is in preventing acute myocardial infarction.”

A study showed that the higher the dose of lipid-lowering drugs (statins), the higher the effect of preventing cardiovascular diseases.

The research team at the Cardiovascular Center at Korea University Guro Hospital (Professors Ji-eun Lee, Ja-yeon Choi, and Seung-woon Na from the Department of Cardiology) found that among the patients who were included in the Korean Acute Myocardial Infarction Registry Study from 2011 to 2015, none of the patients had diabetes, underwent coronary intervention for acute myocardial infarction, and were ‘ taking statins. mortality, and myocardial infarction recurrence according to intensity of statin prescription among 6,152 middle schoolers.

Statins are drugs that not only reduce LDL cholesterol, known as bad cholesterol, but also keep blood vessels healthy, reducing the risk of cardiovascular diseases such as angina, myocardial infarction , and cerebral palsy. These patients were taking atorvastatin or rosuvastatin, which are representative statins.

The research team divided the drug into a high-intensity group (2,405 people) and a moderate-intensity group (3,747 people). 14.1% in the moderate group. In addition, a study of the incidence of new diabetes showed that the high-intensity dose group was 7.8%, which was higher than the moderate-intensity dose group at 5.8%.

In a study based on statin type and dosage, the cumulative incidence of new diabetes was higher in patients taking rosuvastatin at higher doses, but in patients taking atorvastatin, a clear increase in the cumulative incidence of new diabetes depending on the dose. The cumulative incidence of major cardiovascular events according to dosage of atorvastatin was lowest at 8.5% for patients taking 80 mg, 12.0% for patients taking 40 mg, and 15.0% and 19.2% for patients taking taking 20 mg and 10 mg, respectively, decreases significantly as the dosage level increases.

Professor Lee Ji-eun said, “Statins are very important drugs that effectively reduce the risk of cardiovascular disease, and medical guidelines also strongly recommend high-intensity statin treatment for patients with acute myocardial infarction.” The majority of patients treated with statins to develop diabetes, such as those with high blood pressure, hyperlipidemia, obesity, and old age, are not yet known, and no It is still unclear whether statins themselves have an effect on causing diabetes. In addition, although high-intensity statin use was associated with a high incidence of diabetes, statin use can effectively reduce the risk of cardiovascular diseases such as the incidence of major cardiovascular events, total mortality, myocardial recirculation, and reoperation, as well. Therefore, it is very important to take statins according to each person’s situation,” he explained.

The results of this study were published in the latest issue of the international academic journal ‘Scientific Reports’.

Reporter Jeong Jin-su [email protected]

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