An international team of scientists conducted a study in which it established a link between maternal obesity and liver cancer in children.
Experts have identified miRNAs in obese pregnant mice that appear to transmit several generations of susceptibility to liver cancer to their offspring.
One third of the world’s population is overweight or obese, and this a global problem threatens health. Obesity increases the risk of developing metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
Up to 50% of the newly diagnosed HCC in the United States is the result of hepatic metabolic disorders. Obesity of a mother, whose condition directly affects the health of offspring, plays an important role in metabolic diseases, scientists say:
Epidemiological studies show that obesity is an independent risk factor. development of liver cancer. We conducted our study on mice, but we suspect that similar processes occur in humans.
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During the experiment, the researchers injected diethylnitrosamine to cause liver cancer in the obese mice that were fed. high fat diet. RNA sequencing was performed to identify genes and miRNAs that have changed over several generations.
Scientists have found that maternal obesity increased the risk of developing liver cancer in cubs and subsequent offspring several times. For example, problems with biscuits in the offspring of an obese mother and grandmother were more serious than in the offspring of an obese mother and grandmother with a normal weight.
By our research, we would like to call for global efforts to combat maternal obesity, which in the future will affect the health of children. This study also opens up a new pathway for the study of cancer caused by metabolic disorders, – concluded the scientists.
Experts are now studying how maternal stress can affect her offspring.
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