CanSino Biologics Inc announced that its new recombinant coronavirus vaccine has been approved by the Joint Prevention and Control Mechanism of the State Council of China as a heterologous booster, making it the first adenovirus vectored vaccine included in the heterologous vaccination program in China.
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According to the Council of State, for those over 18 years of age who have completed a six-month vaccination program with inactivated covid-19 vaccines, the administration of Convidencia as a heterologous booster can significantly increase the levels of neutralizing antibodies.
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Heterologous booster vaccination refers to the use of vaccine boosters from different technological platforms of the main vaccines, which could improve the general immune response and increase protection against other variants.
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According to a recent study jointly published by the China CAS Key Laboratory of Pathogenic Microbiology and Immunology, the Institute of Microbiology of the Chinese Academy of Sciences, and others, those who received two doses of inactivated vaccine and then received Convidecia had higher levels of antibodies. neutralizing against the prototype strain that were 7 times higher than those boosted with recombinant protein vaccines.
The study found that for the omicron variant, Convidecia generated neutralizing antibody levels 6-fold and 3-fold higher than the groups receiving inactivated vaccines and recombinant protein vaccines, respectively.
In addition, administration of Convidencia as a booster can also induce a significant CD8+T cell immune response, which it could rapidly destroy virus-infected cells and reduce the probability of severe illness and death, providing both humoral and cellular immunity.
A recent interim guide for heterologous vaccination against covid-19 from the World Health Organization (WHO) recommended that people who received an initial administration with inactivated vaccines against covid-19, can choose vaccines with vectors of adenovirals or of mRNA as subsequent booster doses.
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At the moment, Convidecia is approved in more than ten countries, including China, Pakistan, Mexico, Ecuador, Chile, Argentina, Hungary, Kyrgyzstan, Indonesia, and Malaysia, among others.
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