A systematic review of the literature, published in the Journal of Crohn’s and Colitis, highlights the association between perianal Crohn’s disease (pCD) and the risk of developing colorectal carcinoma. The risk was found to be 66% higher in this group compared to CD patients without perianal disease.
The aim of this systematic review was to assess the incidence of and risk factors for colorectal and anal carcinoma in patients with pCD. 5 studies could be included with a total of 29,548 CD patients. Of these, 26.5% had perianal disease. The median follow-up was 6 years (2.9-8.3 years). A total of 127 patients with CD developed colorectal carcinoma (0.43%). Perianal involvement was present in 50% of these patients. In 3 of the studies (involving 23,912 CD patients), tumors were specified as rectal or anal, in 68 and 24 cases respectively (0.3% and 0.1% of patients). In a subgroup analysis of rectal and anal carcinoma, perianal involvement was most common in anal cancer (46% of cases). In the rectal cancer group, 37% had perianal involvement. The higher incidence of colorectal carcinoma in patients with pCD was confirmed in a meta-analysis.
These results support the theory that patients with pCD have an increased risk of developing colorectal and anal cancer. According to the researchers, there is a need for more research on pCD, especially larger, more detailed studies, with better specification of risk factors, demographics, cancer subtypes, cancer stage and histological diagnoses.
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2023-07-07 08:00:59
#Perianal #Crohns #Development #Colorectal #Anal #Cancer #MedNet
