Coenzyme Q10
Animal experiments have confirmed that Coenzyme Q10 (click for complete medication information) mainly has the following pharmacological effects:
1. It can reduce the weakening of myocardial contractility and the content of creatine phosphate and adenosine triphosphate during acute ischemia, maintain the morphological structure of ischemic cardiomyocyte mitochondria, and have a certain protective effect on ischemic myocardium;
2. Increase cardiac output and reduce peripheral resistance, which is beneficial to anti-heart failure treatment. It may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules;
3. When the isolated ventricular muscle of animals is perfused under hypoxic conditions, the action potential duration can be shortened and the threshold for ventricular arrhythmia is higher than that of control animals;
4. It can reduce peripheral vascular resistance and have anti-aldosterone effect;
5. It has anti-cardiotoxic effects and hepatoprotective effects of doxorubicin.
Myocarditis (pixabay)
Due to its broad-spectrum antioxidant mechanism and the fact that Coenzyme Q10 is a non-specific immune enhancer, Coenzyme Q10 is not used alone in clinical use, but as an auxiliary treatment for some diseases.
Currently, oral coenzyme Q10 can be used as an auxiliary treatment for the following diseases:
1. Cardiovascular diseases, such as viral myocarditis and chronic cardiac insufficiency;
2. Hepatitis, such as viral hepatitis, subacute liver necrosis, and chronic active hepatitis;
3. Comprehensive cancer treatment: It can reduce certain adverse reactions caused by radiotherapy, chemotherapy, etc.
Oral administration is usually taken after meals, 1 tablet (10 mg) at a time, 3 times a day.
Coenzyme Q10 for injection is also an auxiliary drug and can be used as an auxiliary drug for congestive heart failure, coronary heart disease, hypertension, arrhythmia, primary and secondary hyperaldosteronism, sequelae of neck trauma, cerebrovascular disorders, hemorrhagic shock and hepatitis adjuvant therapeutic drugs.
Coenzyme Q10 injection can be injected intramuscularly or intravenously: 5-10mg daily, 2-4 weeks as a course of treatment.
Itching (photoAC)
1. The patient should be asked about the history of drug allergy before taking the medication, and should be closely monitored during the medication. If symptoms and signs such as rash, itching, difficulty breathing, drop in blood pressure, etc. occur, the medication should be stopped immediately and treated promptly.
2. Coenzyme Q10 is easily decomposed when exposed to light. During intravenous infusion, please complete the infusion within 2 hours; for long-term infusion, measures should be taken to avoid light.
3. Coenzyme Q10 may appear mist crystals, please check carefully before use. If crystals appear or the drip rate is abnormal during infusion, stop using it immediately.
4. When coenzyme Q10 is combined with other drugs, attention should be paid to the incompatibility of the drugs due to changes in pH and ionic strength. For example, when this product is mixed with tinidazole for injection, a white precipitate will be produced, and when it is mixed with lomefloxacin aspartate solution, yellow flocculation will precipitate. When mixed with ligustrazine for injection, the solubility will decrease and a precipitate will form. When used together, the drugs should be infused separately, and the tubes need to be flushed or changed between uses of the two drugs.
Coenzyme Q10 has a “dual identity”. It is both a drug approved by the State Food and Drug Administration and a legal ingredient in health products.
2023-09-27 08:24:28
#Coenzyme #Q10 #Coenzyme #Q10 #Ubiquinone #Cardiovascular #disease #Hepatitis
