When the mice were examined two weeks later, their cardiac function had improved significantly compared to that of control mice, in which cardiac fibrosis was induced but which were not treated with the CAR-T cells. During the echocardiographic examination of the heart tissue of the mice, the researchers found that the scar tissue in the heart chambers was reduced – in some treated mice even so much that they could no longer be distinguished from healthy control animals. Only scar tissue around the blood vessels remained as this fibrosis is caused by fibroblasts that do not express fibroblast activation protein (FAP).
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