PubMed Abstract

Acute COVID-19 severity markers predict post-COVID new-onset psychiatric disorders: A 2-year cohort study of 34,489 patients

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Acute COVID-19 severity markers predict post-COVID new-onset psychiatric disorders: A 2-year cohort study of 34,489 patients

New-onset psychiatric disorders are frequent after COVID-19. We aim to determine whether acute COVID-19 severity markers can predict post-COVID new-onset psychiatric disorders. We conducted an electronic health records (EHR) cohort study of patients hospitalized for COVID-19 and without any known history of psychiatric disorders. Patients were included between January 2020 and September 2022 in one … Read more

PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

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PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

Background: Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reported. We assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) compared to placebo in preventing development of symptomatic COVID-19 in asymptomatic … Read more

Cryo-EM captures early ribosome assembly in action

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Cryo-EM captures early ribosome assembly in action

Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification of ribosomal RNAs (rRNAs) and ribosomal proteins. To obtain insights into the still unexplored early assembly phase of the bacterial 50S subunit, we exploited a minimal in vitro reconstitution system using purified ribosomal components … Read more

Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort-FIRCOV

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Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort-FIRCOV

Laura Gochicoa-Rangel, Santiago C. Maple, Carlos Aguirre-Franco, Wilmer Madrid-Mejia, Monica Gutierrez-Claveria, Lorraine Noriega-Aguirre, Patricia Schonffeldt-Guerrero, Agustin Acuna-Izcaray, Arturo Cortes-Telles, Luisa Martinez-Valdeavellano, Federico Isaac Hernandez-Rocha, Omar Ceballos-Zuñiga, Rodrigo Del Rio Hidalgo, Sonia Sanchez, Erika Meneses-Tamayo, and Ivan Cherrez-Ojeda; and on Behalf of the Respiratory Physiology Project in COVID-19 (FIRCOV). Effect of altitude on respiratory functional status … Read more

Severe SARS-Cov2 pneumonia in vaccinated patients: a multicenter cohort study

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Severe SARS-Cov2 pneumonia in vaccinated patients: a multicenter cohort study

Vaccination reduces risk of infection, hospitalization, and death due to SARS-Cov2. Vaccinated patients may however experience severe SARS-Cov2 disease. The objective was to describe clinical features of vaccinated patients requiring intensive care unit (ICU) admission due to SARS-Cov2 infection and compare them to a published cohort of unvaccinated patients. We performed a multicenter cohort study … Read more