NIH

Acute COVID-19 severity markers predict post-COVID new-onset psychiatric disorders: A 2-year cohort study of 34,489 patients

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Acute COVID-19 severity markers predict post-COVID new-onset psychiatric disorders: A 2-year cohort study of 34,489 patients

New-onset psychiatric disorders are frequent after COVID-19. We aim to determine whether acute COVID-19 severity markers can predict post-COVID new-onset psychiatric disorders. We conducted an electronic health records (EHR) cohort study of patients hospitalized for COVID-19 and without any known history of psychiatric disorders. Patients were included between January 2020 and September 2022 in one … Read more

NIH awards $6.9 million to prepare potential Alzheimer’s treatment for future clinical trials

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NIH awards .9 million to prepare potential Alzheimer’s treatment for future clinical trials

A multidisciplinary team of scientists led by Carlo Ballatore, Ph.D., of the University of California, San Diego, and Kurt Brunden, Ph.D., of the University of Pennsylvania, has received a $6.9 million grant from the National Institute on Aging (NIA) to prepare a potential disease-modifying treatment for Alzheimer’s disease for future clinical trials. In a recently … Read more

The National Institute of Allergy and Infectious Diseases co-hosted a workshop on mucosal vaccines for COVID-19, with researchers emphasizing the need for improvement. No COVID-19 mucosal vaccines have been authorized for use in the US or Europe, but at least 44 are in preclinical development. The workshop concluded that research into mucosal vaccine development is a priority, and could lead to improved vaccines for other diseases.

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The National Institute of Allergy and Infectious Diseases co-hosted a workshop on mucosal vaccines for COVID-19, with researchers emphasizing the need for improvement. No COVID-19 mucosal vaccines have been authorized for use in the US or Europe, but at least 44 are in preclinical development. The workshop concluded that research into mucosal vaccine development is a priority, and could lead to improved vaccines for other diseases.

The COVID-19 pandemic has had a profound impact on the world, affecting every aspect of life, from work to travel, education to healthcare. While several vaccines have been developed and authorized for emergency use, the race to produce a more effective and convenient vaccine continues. One promising approach is the mucosal COVID-19 vaccine. Unlike traditional … Read more

The National Institute of Allergy and Infectious Diseases hosted a virtual workshop on developing mucosal vaccines for COVID-19, highlighting challenges and opportunities.

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The National Institute of Allergy and Infectious Diseases hosted a virtual workshop on developing mucosal vaccines for COVID-19, highlighting challenges and opportunities.

Since the onset of the COVID-19 pandemic, scientists worldwide have been tirelessly working on the development of vaccines to curb the spread of the virus. While several vaccines have been developed and authorized for use, there is still a need to explore more efficient and effective ways to combat the virus. One promising approach that … Read more

Tranexamic acid doesn’t reduce the need for blood transfusion or maternal death after a cesarean, reveals a study funded by the US National Institutes of Health. Patients given the drug did have a slightly lower drop in red blood cell count and less need for post-partum medical intervention. Tranexamic acid slows the breakdown of blood clots, and was presumed to reduce bleeding, according to previous studies. However, the new study included 11,000 patients across 31 centres and shows no statistically significant benefit to the treatment.

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Tranexamic acid doesn’t reduce the need for blood transfusion or maternal death after a cesarean, reveals a study funded by the US National Institutes of Health. Patients given the drug did have a slightly lower drop in red blood cell count and less need for post-partum medical intervention. Tranexamic acid slows the breakdown of blood clots, and was presumed to reduce bleeding, according to previous studies. However, the new study included 11,000 patients across 31 centres and shows no statistically significant benefit to the treatment.

Cesarean delivery, also known as a C-section, is a common surgical procedure performed to deliver infants when vaginal delivery is not possible or poses risks to the mother or baby. One of the major complications that can arise from a C-section is postpartum hemorrhage, which is excessive bleeding following childbirth. To prevent such bleeding, a … Read more

PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

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PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

Background: Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reported. We assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) compared to placebo in preventing development of symptomatic COVID-19 in asymptomatic … Read more

Cryo-EM captures early ribosome assembly in action

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PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification of ribosomal RNAs (rRNAs) and ribosomal proteins. To obtain insights into the still unexplored early assembly phase of the bacterial 50S subunit, we exploited a minimal in vitro reconstitution system using purified ribosomal components … Read more

Effect of Altitude on Respiratory Functional Status in COVID-19 Survivors: Results from a Latin American Cohort-FIRCOV

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PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

Laura Gochicoa-Rangel, Santiago C. Maple, Carlos Aguirre-Franco, Wilmer Madrid-Mejia, Monica Gutierrez-Claveria, Lorraine Noriega-Aguirre, Patricia Schonffeldt-Guerrero, Agustin Acuna-Izcaray, Arturo Cortes-Telles, Luisa Martinez-Valdeavellano, Federico Isaac Hernandez-Rocha, Omar Ceballos-Zuñiga, Rodrigo Del Rio Hidalgo, Sonia Sanchez, Erika Meneses-Tamayo, and Ivan Cherrez-Ojeda; and on Behalf of the Respiratory Physiology Project in COVID-19 (FIRCOV). Effect of altitude on respiratory functional status … Read more

Severe SARS-Cov2 pneumonia in vaccinated patients: a multicenter cohort study

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PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

Vaccination reduces risk of infection, hospitalization, and death due to SARS-Cov2. Vaccinated patients may however experience severe SARS-Cov2 disease. The objective was to describe clinical features of vaccinated patients requiring intensive care unit (ICU) admission due to SARS-Cov2 infection and compare them to a published cohort of unvaccinated patients. We performed a multicenter cohort study … Read more

Resistance training and clinical status in patients with postdischarge symptoms after COVID-19: protocol for a randomized controlled crossover trial “The EXER-COVID Crossover Study”

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PubMed: A Randomized Double-Blind Placebo-Controlled Clinical Trial Evaluating the Efficacy of Subcutaneous Hyperimmune Immunoglobulin Against COVID-19 in Asymptomatic Individuals with SARS-CoV-2 Infection for Disease Prevention.

Background: Physical exercise induces a coordinated response of multiple organ systems, including the immune system. In fact, it has been proposed that physical exercise may modulate the immune system. However, the potential effect of an exercise program on COVID-19 survivors has not been investigated. Thus, the aim of this study is to evaluate the modifications … Read more