New Insights on Genetic Mutations in Neurodegenerative Conditions: Impact of CAG Repeat Expansion and RNA Aggregates
Previous studies have revealed that neurodegenerative conditions, including Huntington’s disease and spinocerebellar ataxia, are triggered by an increase in the number of trinucleotide CAG repeats in the coding gene, generating an expansion of the polyglutamine tract within a protein. These disorders are hereditary because the expansion of CAG repeats in the coding gene is passed … Read more