Researchers at Weill Cornell Medicine have found that protein built-up in astrocytes could trigger abnormal antiviral activity and memory loss in those with dementia. The study could lead to treatments that reduce immune activity in astrocytes to improve cognition. Drugs that target the immune pathways already exist and may be repurposed for dementia treatments. Previous research shows links between viral infections and cognitive dysfunction, which could be exacerbated by astrocyte immune activity. The team is now studying how TDP-43 changes the antiviral activities in astrocytes and whether it increases brain susceptibility to viral pathogens.
As we age, our cognitive abilities undergo slow but significant changes. It is not uncommon for some individuals to experience memory loss, difficulty concentrating, and other cognitive impairments. While some of these changes are considered a normal part of aging, researchers have discovered a link between cognitive decline and problems with astrocytes – a type … Read more