Written by Mervat Rashad Sunday, December 17, 2023 01:00 PM
A recent study published in the journal Science Advances, conducted by the Gladstone Institutes of the University of California, San Francisco, confirmed that breathing air containing… amount of oxygen More than what the body needs, can lead to health problems in the lungs and heart and cause death, according to what was published by the “hindustantimes” website.
The study showed that breathing air with different levels of oxygen, from too little, to completely adequate, or too much, affects the formation and degradation of various proteins in the lungs, heart, and brain of mice. The study highlighted a specific protein that may play a key role in regulating how cells respond. For hyperoxia, the results indicated that it has effects on many different diseases.
Kirsten Shiwen Chen, the first author of the study at the University of California, San Francisco, said that breathing a large amount of oxygen leads to the degradation of some proteins that contain iron and sulfur groups, which leads to cell dysfunction.
Regarding how proteins are regulated when oxygen levels are very high or low, the researchers confirmed that oxygen levels significantly affected proteins in the lungs of mice compared to the heart or brain, and they identified specific proteins with abnormal turnover rates under high or low oxygen conditions. One particular protein that accumulates in high-oxygen conditions, MYBBP1A, is a transcriptional regulator, meaning it directly affects gene expression.
Other experiments have shown evidence suggesting that accumulation of this protein in the lungs, in response to high oxygen levels, may affect the production of RNA, a major component of ribosomes.
The team of researchers examined the precise molecular role of MYBBP1A during hyperoxia, including whether its response is protective or harmful. This work could pave the way for new therapies that target MYBBP1A or related molecules in ways that counteract the ill effects of hyperoxia – similar to broad research efforts. The range targets HIF proteins in low oxygen conditions.
2023-12-17 11:00:00
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