05:00 a.m
Thursday, October 17, 2024
A group of researchers revealed the serious consequences of sperm defects, as they increase pregnancy problems and have a negative impact on the health of the child, according to the Medical Express website.
A team of researchers has linked, for the first time, specific recurrent sperm defects to the risk of pregnancy complications and adverse effects on the child’s health.
A study conducted at the University of Lund in Sweden showed that a high percentage of the father’s sperm containing damaged DNA is associated with a doubling of the risk of preeclampsia in women who are pregnant with the use of insecticides. artificial, and also increases the risk of the child being born prematurely. .
It seems that about 20-30% of children born through IVF have fathers with damaged DNA in their sperm, as shown by high levels of DNA breakage.
The DNA breakage index (DFI) is a measure of the level of damage and is used to provide important new information about male fertility.
Sperm with damaged DNA can still be fertile, but the chance of fertilization is lower, and if the DNA breakage index is higher than 30%, the chance of natural pregnancy is close to zero.
Alexander Gewerkman, professor of reproductive medicine at Lund University, led a research study that included 1,660 children conceived through artificial insemination and ICSI at the Center for Reproductive Medicine in Malmö, in the period from 2007 to 2018.
The results showed that, in 841 couples who underwent IVF, a DFI increase of more than 20% doubled the risk of preeclampsia women (10.5%) and also increased the risk of premature birth.
In the IVF group with a DFI of less than 20%, there was a 4.8% risk of preeclampsia, which is equivalent to a naturally occurring pregnancy.
“Today, DFI analysis is only performed in some fertility clinics in Sweden, but we believe that it should be offered as standard in all clinics,” said Gwerkman. Not only that, our recent findings show that DFI analysis can be used to identify high-risk pregnancies. “
It is worth noting that most cases of DNA damage occur due to oxidative stress, which is an imbalance between harmful molecules and antioxidants that protect cells. Other factors that increase DNA breakage include a person’s age, smoking, obesity, and disease.
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2024-10-17 02:00:00
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