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The feeling of loneliness, a growing concern in the United States, may be more perilous than previously thought. A new study published in Nature Human Behaviour reveals a notable link between social isolation and loneliness and an increased risk of serious health problems, including heart disease and stroke.
Researchers from the University of cambridge and Fudan University analyzed blood samples from over 42,000 adults aged 40 to 69 participating in the UK Biobank. Their findings point to specific blood proteins as potential key players in this connection. “One way to explore biological mechanisms is to look at proteins circulating in the blood,” the researchers explain.
The Role of Blood Proteins
The study identified 175 proteins associated with social isolation and 26 with loneliness. many of thes proteins are involved in inflammation, viral infection, and conditions such as cardiovascular disease, type 2 diabetes, and stroke. the presence of these proteins in higher quantities in socially isolated or lonely individuals suggests a direct biological pathway linking social connection to physical health.
One protein, ADM, stood out. Found in higher levels in lonely individuals, ADM regulates stress and social hormones like oxytocin. the researchers note, “the higher the ADM levels, the lower the volume of the insula, a brain region that allows us to sense what is happening inside our body.” Another protein, ASGR1, was also linked to higher cholesterol levels and increased cardiovascular risk.
These findings underscore the importance of social connection for overall well-being. Professor Barbara Sahakian, from the University of Cambridge’s psychiatry department, emphasizes, “These results highlight the importance of social contacts for our health. More and more people of all ages report feeling alone. This is why the World Health Association has described social isolation and loneliness as a global public health problem. We need to find ways to combat this growing problem and maintain connections between people to help them stay healthy.”
The implications of this research are far-reaching, particularly in the U.S., where feelings of isolation and loneliness are prevalent across various demographics. The study highlights the need for increased awareness, preventative measures, and community initiatives to combat social isolation and its detrimental effects on public health.
Loneliness and social isolation are more than just feelings of sadness—they can have a profound impact on our physical health. A new study published in
Nature Human Behavior reveals a direct link between social connection and our biology.
Senior Editor,
World Today News
WORLD TODAY NEWS: Dr. Carter, tell us about the key findings of this study.
DR. EMILY CARTER: This groundbreaking study, conducted by researchers at the University of Cambridge and Fudan University, analyzed blood samples from over 42,000 participants. They discovered specific proteins linked to both social isolation and loneliness. These proteins are involved in inflammation, viral infections, and conditions like cardiovascular disease, type 2 diabetes, and stroke.The presence of these proteins in higher amounts suggests a direct biological pathway between our social connections and our overall health.
WORLD TODAY NEWS: Could you elaborate on the role of these proteins? Were there any that stood out?
DR. EMILY CARTER: One protein, adenosine deaminase (ADM), was notably engaging.It’s involved in regulating stress hormones and social hormones like oxytocin. The study found higher ADM levels in individuals who reported feeling lonely. Interestingly, higher ADM levels were also linked to a reduced volume in the insula, a brain area crucial for sensing bodily sensations. This suggests a possible connection between loneliness, ADM, and how we perceive our physical state.
Another protein, asialoglycoprotein receptor 1 (ASGR1), was linked to higher cholesterol levels and increased cardiovascular risk in socially isolated individuals.
WORLD TODAY NEWS: Why is it crucial for people to understand this connection between social connections and physical health?
DR. EMILY CARTER: This research underscores the critical nature of social connections for our well-being. Loneliness and social isolation are not simply emotional concerns;
they can have tangible, measurable impacts on our bodies, increasing our risk for serious health problems. Recognizing this link is vital because it emphasizes the need for preventative measures and interventions.
WORLD TODAY NEWS: What can individuals and communities do to combat loneliness and social isolation?
DR. EMILY CARTER: It’s important to create supportive environments that prioritize social connection. This can involve encouraging people to engage in social activities, supporting community initiatives that bring people together, and raising awareness about the importance of social well-being. For individuals who are experiencing loneliness, seeking out social groups, volunteering, and connecting with friends and family can all be helpful steps.
WORLD TODAY NEWS: Thank you, Dr. Carter, for sharing your valuable insights on this important topic.
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