“Small” Clade 1b spreading fast ..high death toll

He became shocked again by mutation ofthe pox or MPox Recently, 1 patient was found in Thailand.

Hans Kluge The World Health Organization (WHO) Regional Director for Europe provides information through their website.World Health Organization (WHO) that Mpox is a viral infection that causes purulent sores. Symptoms are similar to the flu, it is not serious, but they can cause death For Mpox clade 1b, it is a mutation from the original strains, Clade 1 and Clade 2, and it can spread more easily. Through regular close contact Around 100 new cases of Clade II are currently being reported in the European region each month. This is especially true among people who have traveled to outbreak areas in Africa. First, vaccination is the best defense against disease.

however Tarik Jasarevich A WHO spokesperson said that the WHO does not recommend mass vaccination. But the vaccine is recommended in places with outbreaks, such as in the Congo. Among those at risk, WHO has now declared smallpox (MPox) an “international public health emergency” in some areas of Africa.

Information from news websites Health Focus Specify the interview statement from Prof. Emeritus Dr Wasan Chandratathit Head of the Medical Genome Center Faculty of Medicine Ramathibodi Hospital has a series of attacks (Mpox or Monkeypox) called Clade 1 (Clade 1) and Clade 2 (Clade 2). (Cemetery 1b) which are easy to contact But the death rate is only 1%.

The head of Medical Genome Center Ramathibodi said Smallpox Clade 1B Clade 1b is a species that has adapted to be more easily caught. From the beginning it was very difficult to contact them. Must touch each other closely Found mostly in MSM. But this time has changed. especially in the Republic of Congo It is easier to contact. Currently, about 18,000 people are infected with clade 1B, and more than 500 have died.

“70% of the deaths were children, showing that it is easier to be infected with this strain. people living in the same house For example, young children can spread germs. Through secretions, coughs and sneezes Find data from Africa that People who are sick and stay in the same house for about 4 hours are at risk of infection. both from contact with germs from secretions Using hands that have touched the virus to rub your eyes, cough or sneeze, which is not related to sex,” said Prof. Emeritus Dr Wasan.

So far, the reason remains unclear. Why are diseases increasing so quickly? But viruses try to insert themselves into the human body. The incubation period is 22 days If a Thai travels to high risk countries like Africa or DR Congo When you return, please check yourself for flu-like symptoms. Do you have a rash on your body? If so, you need to see a doctor immediately. Reporting in the data reporting system from hospitals to the Department of Disease Control.

Prof. Emeritus Dr Wasan He said that there is currently a vaccine to prevent this disease. Introduced by the Thai Red Cross Society Can be applied before and after travel to high-risk groups. with past information If exposed to a disease It can prevent 68-80% of violence, but a vaccine to prevent this disease must be paid out of pocket because it is not still covered by the health insurance system.

“Emphasis on avoiding travel to high-risk countries where smallpox is spreading. Especially Clade 1b types of smallpox in African countries or in the Democratic Republic of Congo. Please avoid it now. Pregnant women in particular should not travel to these high-risk countries. Because medical information has been found Clade 1B smallpox can be transmitted from mother to child,” said Dr. Emeritus Dr Wasan and said. If it is necessary to travel to a place where smallpox appears. Please strictly protect personal hygiene. Completely avoid contact with animals that may be carrying the virus, such as rats, monkeys, or other rodents.

Apparently, previously the Genome Center no Center for Medical Genomics Information posted via Facebook says that the enzyme “APOBEC-3” in the human body has an important role in accelerating the mutation of the smallpox virus at the genome level. This is consistent with data on the smallpox outbreak in 2022 which was found to be linked to genetic changes due to the enzyme APOBEC3, which is an enzyme of the human body’s natural immune system. It plays a role in creating mutations in the genome of the virus. Leads to the evolution and change of germs.

From the study it was found that Smallpox virus clade IIb Many mutations are caused by the enzyme APOBEC3, which changes the genetic code from C to T and G to A on the virus genome. Although this response is intended to destroy the virus, But it was found that these mutations helped the virus to change and multiply in the human body better. As a result there is a higher potential for the virus to spread.