Aaron Judge hit his major league-leading 45th home run of the season for the Yankees, who have lost eight of 10.
Thanks to two tense one-run wins, Seattle won two of three from New York for the second week in a row to win the season series 4-2.
Kyle Higashioka hit a two-run homer in the 115th and Seattle starter Robbie Ray’s final pitch in the seventh to snap a 19-inning scoreless streak for the Yankees, and Judge against Penn Murfee (3-0) made it 3-1. later in the frame.
Murfee then retired DJ LeMahieu and Anthony Rizzo, Diego Castillo pitched a perfect eighth and Paul Sewald pitched the ninth for his 15th save.
Albert Abreu (2-2) left a changeup in the middle of the plate and Santana drove in to score Mitch Haniger.
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