“Scientists use AI to discover new antibiotic to combat deadly superbug”

Stokes, an assistant professor in the Department of Biomedicine and Biochemistry at McMaster University, led the study.

In the study, the researchers first trained the AI ​​to learn the chemical properties of drugs that work against Acinetobacter baumannii. They then asked the AI ​​to sift through a list of 6,680 potential compounds, and found the potent antibiotic Abaucin.

The results of the study showed that it only took one and a half hours for the AI ​​to produce a condensed list of hundreds of compounds, and then 240 of them were tested in the laboratory, and finally 9 potential antibiotics were found, and then these 9 antibiotics were tested in mice. In the body wound infection model test, Abaucin finally came to the fore.

The new antibiotic Abaucin can kill the deadly superbug Acinetobacter baumannii.

However, the improvement and clinical trials of Abaucin are still in progress. It is expected that the first AI antibiotics may not be available for prescription until 2030.

Most notably, this antibiotic is ineffective against other bacteria and only works against Acinetobacter baumannii. This precise mode of action could help reduce the emergence of drug resistance and potentially reduce side effects.

The researchers emphasize that the power of AI can screen tens of millions of potential compounds, which cannot be achieved by manual work. Therefore, AI has the potential to greatly improve the speed and efficiency of discovering new antibiotics in the medical community.

A postgraduate student at McMaster University in Canada who participated in the research.

A. baumannii can survive for extended periods of time in environmental services and shared equipment, and can be transmitted through contaminated hands. In addition to bloodstream infections, Acinetobacter baumannii can also cause urinary tract and lung infections.

The bacteria are inherently able to find new ways to resist treatment and can pass on genetic material that makes other bacteria resistant, the WHO said.

Scientists have discovered that the new antibiotic Abaucin can kill the deadly superbug Acinetobacter baumannii.