Scientists have identified the best combination of vaccines to protect against COVID-19

The combination of some vaccines, according to scientists, increases the body’s immune response to coronavirus by 17 times.

Scientists at the University of Oxford have found that combining different vaccines during the COVID-19 vaccination process increases the production of neutralizing antibodies in T cells, compared with the indicators after immunization with a mono vaccine. These are vaccines such as Pfizer, AstraZeneca, Moderna and Novavax. It is reported by The Guardian.

Scientists analyzed data from 1,070 Britons who were first vaccinated with the AstraZeneca or Pfizer vaccine, and after 9 days were vaccinated with either a similar drug or the development of Moderna or Novavax. As it turned out, those who combined the AstraZeneca and Moderna vaccines received 17 times higher levels of antibodies in their bodies compared to those who were vaccinated with two doses of AstraZeneca. And those who received the second dose of Novavax after the first AstraZeneca vaccination showed a 4-fold increase in the level of antibodies.

“We saw that just because you got one dose of a particular vaccine doesn’t mean you should get the same vaccine as a second dose,” said Matthew Snape, professor at Oxford University.

The combination of Pfizer and Moderna vaccines showed the following result – after the first Pfizer vaccination and the second Moderna dose, the level of neutralizing antibodies was 1.3 times higher, but at the same time, after the Novavax injection, the antibody level was 20% lower than after two doses of Pfizer.

The scientists noted that the vaccinated subjects showed different T-cell responses after combinations of different types of vaccines, namely mRNA of Pfizer and Moderna vaccines and vector vaccines such as AstraZeneca and protein-based vaccines such as Novavax.

Thus, two doses of the AstraZeneca or Pfizer vaccine resulted in the same number of T cells, the combination of the AstraZeneca vaccine with the second dose of Moderna resulted in 3.5 times more T cells, and the second dose of Novavax showed an increase in the number of T cells by 4.8 times.

For Pfizer, the second dose of Moderna increased the number of T cells by 1.5 times, while the second dose of Novavax resulted in a decrease in the number of T cells.

“This tells us that RNA vaccines and viral vector vaccines do something completely different when it comes to priming the T cell response,” concluded Snape.

Earlier it was reported that scientists found out the mechanism of blood clots in people who have received the AstraZeneca vaccine. However, blood clots are rarely formed and under a number of unfavorable circumstances.


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