PRIANGAN ZONE – Bioengineer at Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has succeeded in creating a biohybrid model of the human ventricle. This discovery will pave the way for the creation of artificial heart.
The manufacture of the human heart is very important because the heart cannot repair itself after injury like other organs. However, to do so, the researchers needed to replicate the heart’s complex structure that includes the helical geometry responsible for the circular motion when the heart beats.
Although it is believed that circular motions are important for pumping high volumes of blood, para scientist can’t prove it. This is partly because creating hearts of different geometries is a tricky job. In a new study published in Science, researchers scientist have been able to show that muscle alignment increases the amount of blood that the ventricles can pump when they contract.
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“This work is a major step forward for organ biofabrication and brings us closer to our ultimate goal of building a human heart for transplantation,” said Kit Parker, Tarr Family Professor of Bioengineering and Applied Physics at SEAS and Applied Physics at SEAS and senior author. this paper, quoted by ZonaPriangan.com from NDTV.
In order to reach this conclusion, the scientist developed a new method of textile additive manufacturing, Focused Rotary Jet Spinning (FRJS). This allows them to create aligned helical fibers with diameters ranging from a few micrometers to hundreds of nanometers.
With this model, the scientist tried to test the hypothesis of Edward Sallin, former chair of the Department of Biomathematics at the University of Alabama Birmingham School of Medicine, who claims that helical alignment is critical for large ejection fractions.
“The human heart actually has several layers of muscles arranged helices with different angles of alignment. With FRJS, we were able to recreate that complex structure in a very precise way, forming single and even four-chambered ventricular structures,” explains Huibin Chang, postdoctoral fellow at SEAS and co-author of the study.***
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