Written by Amal Allam Sunday, August 06, 2023 11:23 AM
Scientists at a leading US hospital have developed a “cancer-killing pill” that kills solid tumors through “targeted chemotherapy.” This protein was developed by a research team at City of Hope, one of the largest cancer research and treatment institutions in the United States. The AOH1996 molecule works by targeting PCNA protein, which is an important protein for DNA replication.
According to the Independent newspaper, scientists have come up with a tablet that has been developed over the past two decades, and has shown its effectiveness in treating many types of cancer, including breast and prostate cancer. It has been developed over the past two decades, and has shown its effectiveness in preclinical research to treat cancer. Breast, prostate, brain, ovaries, cervix, skin and lung.
The study, published in the journal Cell Chemical Biology, tested the protein across more than 70 cancer cell lines. The results indicated that the molecule AOH1996 selectively kills cancer cells by “disrupting the normal cell cycle.” The next phase aims to advance clinical trials in humans. .
“The data suggest that PCNA may be uniquely altered in cancer cells, and this fact allowed us to design a drug that targets only the form of PCNA in cancer cells,” said Dr.
Our cancer-killing pills are like a blizzard that shuts down the main centers that carry cancer cells and prevents them from entering, indicating that the results were promising, as the molecule AOH1996 can suppress tumor growth as a monotherapy or combination therapy in cell and animal models without causing toxicity, currently experimental chemotherapy In Phase 1 human clinical trials at City of Hope.”
No one had previously targeted PCNA as a line of treatment because it was seen as indestructible, but City of Hope clearly has Hope was able to develop an investigational drug for a difficult protein target.
He added, “We have discovered that PCNA is one of the possible causes for the increase in DNA replication errors in cancer cells, and now that we know the problem area and can prevent it, we will dig deeper to understand the development process.” Cancer drugs Most personalized and targeted.
2023-08-06 08:23:00
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