Science reveals how the TB vaccine, and may also be able to deal with COVID-19

Finally, more clarity on how the vaccine enhances our immune system.

One hundred years ago, it was the one and only effective vaccine against TUBERCULOSIS has been developed. The vaccine, Bacillus Calmette-Guérin, or as the BCG matrix, it is, since that time, all of the billions of people’s attention. And quite easily found the vaccine to be an interesting ‘side-effect’ is. The people that are in the vaccine to be administered were to be had but also a lot less prone to infection. It was as if the vaccine and the immune system in one way or the other enhanced.

COVID-19
Although all of these years, it remained unclear how this vaccine is to made people less susceptible to other infections, it was decided researchers this year to test it out and see if it is also a safeguard for all of COVID-19. The medical staff at the Radboudumc was given, the vaccine is administered, in the hope that their immune systems are them also have to strengthen the protection for the virus in SARS-CoV-2 has caused the disease, COVID-19. The results of this study are not quite there yet. And, therefore, it remains unclear as to whether the vaccine will only protect you from COVID-19. However, thanks to a new research, scientists now know how to have the vaccine, the immune system changes.

The study
An international team of researchers, including scientists from the Radboudumc has fifteen volunteers, with the BCG vaccine, and vaccinated. Five others were given a placebo) are administered. Three months later, we’re both in the blood as a beenmergmonsters one of these people has declined,” according to researcher Mihai Netea of the Radboudumc.

Cytokines
The study points out that there are a few notable differences between the samples from the BCG-vaccine, the vaccinated persons, samples taken from people who were a placebo, administered for get. Thus, it appeared that the immune cells in the blood of the people with the real vaccine is injected, there were more cytokines to be produced. These cytokines amplify the immune response by, for example, they have other immune cells for help, ask for it at the site of infection, leading to. Moreover, it turned out to be the immune cells of persons who have the BCG vaccine is administered, and received, an activity to be found in other genes of the immune cells in the placebo group, in particular at the genes that are necessary for the production of cytokines.

Long-term change
The researchers have traced the mechanisms of these changes are at the origin. As it turns out, the BCG vaccine, the long-term changes to be the cause of the genetic programming of hematopoietic stem cells in the bone marrow, which, put simply, of all the immune cells originate. “We have found that certain genetic material be after a vaccination and more accessible it is, what it means is that the more the cells are “read” to be,” says researcher Andreas Schlitzer, an affiliate of the university of Bonn. You should keep in mind that each and every human cell has tens of thousands of genes in hosts which, again, serves as a sort of installation instructions for different kinds of molecules. If a cell contains a certain molecule such as a cytokine are trying to create, it needs to find the appropriate installation instruction. However, not all of the genes, or instructions for assembly are easy to access. The BCG-vaccination, it appears, however, to make sure that the particular instructions for many, many months, or even years to be more accessible. This is particularly so in the installation instructions, which have a higher production of regulatory t-cells as well. “That is why the vaccination leads to an enhanced immune response for a longer period of time.” according to Netea. And why not give to people even a long time after that, the immune cells, that is, at the time of vaccination, the blood is circulated though a long time has disappeared, there is still a more powerful immune response and to exhibit it in response to other infections.

The results can also be relevant in the fight against the COVID-19. It is hoped that the vaccine, in the same manner as described above, also in the immune response to COVID-19 and is strengthened so that the disease is of a mild gradient, you know. It is unclear, however, whether it actually works that is still to be sorted out. In the lead-up to examine, guess WHO, a large-scale vaccination with the BCG vaccine, and print. That could, in fact, pose a threat to the stocks in the tuberculosegebieden. The vaccine, even after 100 years, still much in need of the disease for which it has been developed to combat it; the TB still takes more than a million deaths and making it the most deadly infectious disease in the world.