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S2H97, the ‘superantibody’ capable of blocking variants of SARS-CoV-2 and other coronaviruses

Novel discovery the one who has made a team of researchers from the Fred Hutchinson Center that can contribute to the development of new vaccines against coronavirus or the generation of therapies for people who are infected.

The experts have achieved identify a ‘superantibody’ capable of fighting SARS-CoV-2 (and its variants) and other coronaviruses Similar. At the moment, the various strains found reduce the action of vaccines, since the virus has changed since its initial appearance and is more elusive against some defenses. In this analysis 12 different antibodies have been experimented with from people who had the disease.

Prevent infection

The role of all these defenses analyzed is to adhere to the protein S that the coronavirus uses to infect human cells. Thus, this structure of the disease functions as a key and is rendered useless by human defenses. so that it cannot open the host’s cells. The problem is that mutations are emerging, right in that part of the virus, which allow you to bypass this blockage.

After comparing these dozen antibodies, one has stood out above all: S2H97. It always managed to fixate on the key part of the pathogen and no mutation could get away from it. This makes the experts think that it is a ‘superantibody’ capable of preventing infection or contributing to healing.

Less mutational capacity

Attack an almost unknown area of ​​the coronavirus so far and very little visible. It only appears when SARS-CoV-2 removes its S proteins to infect the cell. But then, S2H97 it reveals that essential part that remains hidden the rest of the time.

Specialists have also highlighted the utility of the other 11 antibodies, but they point out that the most versatile are those that they target areas of the virus that show less ability to mutate.

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