A group of researchers in China has identified that the loss of function of a key ion channel in the brain may be a contributing factor in the accumulation of a devastating and toxic protein responsible for the formation of plaques in Alzheimer’s disease.
This discovery represents an important step toward the potential development of therapies for this neurodegenerative condition.
Chinese researchers have shown in animal model studies that manipulating this ion channel, known as TRPM7, can influence the amount of beta-amyloid (β-amyloid) protein – a key feature of Alzheimer’s disease – in the brain. Beta-amyloid protein accumulates in deposits between neurons and disrupts their normal functioning.
The TRPM7 channel is crucial in the process of ion transport in cells and plays an important role in essential cellular activities such as excitability, plasticity and metabolism. It also has a kinase function, catalyzing the transfer of high-energy phosphate groups.
Studies have shown that dysfunctions of the TRPM7 channel are not only associated with Alzheimer’s disease, but also with other neurodegenerative conditions.
In their research, Chinese scientists noticed that the activity of the TRPM7 channel is reduced in Alzheimer’s patients and in animal models affected by this condition. By manipulating the level of TRPM7, the team was able to restore cognitive function in the mice and reduce the accumulation of beta-amyloid protein in their brains.
However, Alzheimer’s research is complex, and amyloid plaques have not yet been clearly identified as a primary cause or just a side effect of the disease. In addition to amyloid plaques, neurofibrillary tangles, made up of tau protein, play a significant role in this condition.
Although current research shows that manipulation of the TRPM7 channel can influence the accumulation of beta-amyloid protein and help restore cognitive function in animal models, more studies are needed to fully understand the implications of this discovery and its therapeutic potential for treating Alzheimer’s disease.
This condition represents a major challenge to the global health system, and finding effective treatments is essential to address its devastating impact on the aging population.
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2023-08-31 19:57:36
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