Two researchers research nucleoside modification. which has led to the development of a vaccine to prevent COVID-19. Types of RNA (mRNA) join together to win the 2023 Nobel Prize in Medicine
Today (2 Oct.) the Nobel Committee of Karolinska Institute in Stockholm, Sweden Announcement of the Nobel Prize in Physiology or Medicine, which is the first award of the 2023 Nobel Prize announcement, which goes to Prof. Dr. Gotolin Goriko, a Hungarian, Senior Vice President. BioNTech RNA Pharmaceutical Company and Prof. Dr. Drew Wiseman, an American from the Faculty of Medicine University of Pennsylvania, United States, who jointly invented and developed the RNA vaccine (mRNA).
Prof. Dr. Gotolin Gorico and Prof. Dr. Drew Wiseman
The Nobel Prize committee announced that the discovery and modification of molecular structures or some nucleosides of messenger RNA (mRNA) using pseudouridine (pseudouridine), which is a component of the genetic material RNA found in nature This causes the human body to have almost no reaction against the mRNA strands that are injected to prevent or treat disease. This makes this technique the basis for producing a COVID-19 vaccine. Effective in the end
“The work of inventing and developing the RNA vaccine of both It has helped save the lives of millions of people around the world. Amidst the COVID-19 pandemic crisis Until global society can open the door to return to normal life again. And currently, RNA vaccines are still being developed. to prevent and treat other diseases such as cancer as well.” Representatives of the Nobel Prize in Physiology Committee or the doctor said
BBC Reported that in 2021 Prof. Dr. Gorico and Prof. Dr. Wiseman Has previously received the Prince Mahidol Award in the medical field. He received this award from Her Royal Highness Princess Maha Chakri Sirindhorn. Her Royal Highness Princess Maha Chakri Sirindhorn Princess Maha Chakri Sirindhorn
In terms of developing mRNA lines that are durable and not easily broken down. and does not stimulate the immune system until resistance arises when introduced into the human body A number of scientists have been trying to find a technique that works for decades. But this was not successful because mRNA is a negatively charged molecule with an open structure that can be exposed to the environment. This is different from the closed helix structure of DNA which is stronger.
Until the 90s, Prof. Dr. Corico was facing the problem of a lack of research funding. Until losing his job in a laboratory at the University of Pennsylvania, he met Prof. Dr. Wiseman and joined the research team of the Faculty of Medicine. to develop an mRNA vaccine that protects against HIV This later became the basis for the production of a Covid vaccine that provides high levels of immunity against the SARS-CoV-2 virus.
The two researchers will jointly receive a total of SEK 10 million in prize money. The official Nobel Prize ceremony will be held in Stockholm this December.
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2023-10-02 11:54:47
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